Engineered immune cells take on tough autoimmune diseases
NCT ID NCT07473154
First seen Mar 16, 2026 · Last updated May 16, 2026 · Updated 8 times
Summary
This early-stage trial tests an experimental treatment called QEL-005 in 16 adults with two serious autoimmune conditions: diffuse cutaneous systemic sclerosis and difficult-to-treat rheumatoid arthritis. QEL-005 is made from a patient's own white blood cells, which are genetically modified to become CAR-T regulatory cells that target B cells. The study aims to check safety, tolerability, and whether the treatment can reduce disease activity, with participants followed for up to 15 years.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Guy's & St Thomas NHS Foundation Trust
NOT_YET_RECRUITINGLondon, United Kingdom
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Leeds Teaching Hospitals NHS Trust
RECRUITINGLeeds, United Kingdom
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Newcastle Upon Tyne NHS Foundation Trust
RECRUITINGNewcastle, United Kingdom
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Royal Free London NHS Foundation Trust
NOT_YET_RECRUITINGLondon, United Kingdom
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University Hospitals Birmingham NHS Foundation Trust
NOT_YET_RECRUITINGBirmingham, United Kingdom
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University of Oxford - The Kennedy Institute
RECRUITINGOxford, United Kingdom
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Conditions
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