Can a simple pill get your gut moving again after surgery?
NCT ID NCT05334485
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether pyridostigmine, a drug that stimulates bowel activity, can safely and effectively treat postoperative ileus—a common condition where the bowels stop working after colorectal surgery. About 50 adults who develop ileus after elective colorectal surgery will receive either pyridostigmine or a placebo, alongside standard care. Researchers will measure how quickly bowel function returns and track any side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pyridostigmine bromide (a drug that stimulates bowel muscle activity)
What this could lead to
If it works, this could offer a safe, simple way to get the bowels moving again after colorectal surgery, shortening hospital stays.
What could go wrong
This is a small, early-phase trial with only 50 participants, so results may not apply to everyone. Side effects like nausea or diarrhea are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cleveland Clinic Main Campus
RECRUITINGCleveland, Ohio, 44195, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••