Can a simple pill get your gut moving again after surgery?

NCT ID NCT05334485

Recruiting now Symptom relief Sponsor: Stefan Holubar MD MS FACS, FASCRS Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether pyridostigmine, a drug that stimulates bowel activity, can safely and effectively treat postoperative ileus—a common condition where the bowels stop working after colorectal surgery. About 50 adults who develop ileus after elective colorectal surgery will receive either pyridostigmine or a placebo, alongside standard care. Researchers will measure how quickly bowel function returns and track any side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pyridostigmine bromide (a drug that stimulates bowel muscle activity)
What this could lead to: If it works, this could offer a safe, simple way to get the bowels moving again after colorectal surgery, shortening hospital stays.
What could go wrong: This is a small, early-phase trial with only 50 participants, so results may not apply to everyone. Side effects like nausea or diarrhea are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

paralytic ileus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTOPERATIVE ILEUS

Contacts and locations

Locations

Cleveland Clinic Main Campus
RECRUITING

Cleveland, Ohio, 44195, United States

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