New drug combo aims to shrink liver tumors in First-Line patients
NCT ID NCT07291076
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new drug called pumitamig, alone or with another drug (ipilimumab), in people with advanced liver cancer that cannot be removed by surgery. The trial includes 198 participants who have not had prior cancer treatment. The goal is to see if the drugs are safe and can shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pumitamig (a drug) and ipilimumab (an immunotherapy drug)
What this could lead to
If successful, this could provide a new treatment option for people with advanced liver cancer who have not had prior therapy.
What could go wrong
This is an early-phase trial (Phase 1/2) with a small number of participants, so the drugs may not work or could cause serious side effects. Results may not apply to all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Contact
Locations
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Bradfordhill
RECRUITINGSantiago, Santiago Metropolitan, 8420383, Chile
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CHU Bordeaux Haut-Leveque
RECRUITINGPessac, Aquitaine, 33600, France
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Cancer Research UK - The Beatson Institute for Cancer Research (Cancer Research UK Beatson Laboratories)
RECRUITINGGlasgow, South Western Scotland, G611BD, United Kingdom
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Centre Hospitalier Universitaire de Grenoble
RECRUITINGLa Tronche, Auvergne-Rhône-Alpes, 38700, France
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Hammersmith Hospital
RECRUITINGLondon, London, City of, W12 0HS, United Kingdom
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Hospital General Universitario Gregorio Marañon
RECRUITINGMadrid, 28007, Spain
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IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
RECRUITINGMeldola, Emilia-Romagna, 47014, Italy
Contact Phone: •••-•••-••••
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John Theurer Cancer Center at Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601-2191, United States
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Local Institution - 0001
NOT_YET_RECRUITINGMontpellier, Languedoc-Roussillon, 34295, France
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Local Institution - 0003
NOT_YET_RECRUITINGBobigny, 93000, France
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Local Institution - 0008
NOT_YET_RECRUITINGKashiwa, 277-8577, Japan
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Local Institution - 0009
NOT_YET_RECRUITINGSingapore, 119074, Singapore
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Local Institution - 0011
NOT_YET_RECRUITINGSeoul, Seoul-teukbyeolsi, 05505, South Korea
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Local Institution - 0012
NOT_YET_RECRUITINGSingapore, 169610, Singapore
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Local Institution - 0013
NOT_YET_RECRUITINGSeoul, Seoul Teugbyeolsi, 06351, South Korea
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Local Institution - 0014
NOT_YET_RECRUITINGPamplona, Navarre, 31008, Spain
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Local Institution - 0015
NOT_YET_RECRUITINGBarcelona, 8036, Spain
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Local Institution - 0016
NOT_YET_RECRUITINGPisa, 56126, Italy
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Local Institution - 0017
NOT_YET_RECRUITINGOsakasayama-shi, Osaka, 5898511, Japan
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Local Institution - 0018
NOT_YET_RECRUITINGSaint Priest En Jarez, Pays de la Loire Region, 42270, France
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Local Institution - 0020
NOT_YET_RECRUITINGGdansk, 80-952, Poland
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Local Institution - 0021
NOT_YET_RECRUITINGWroclaw, Lower Silesian Voivodeship, 53-439, Poland
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Local Institution - 0026
NOT_YET_RECRUITINGMainz, 55101, Germany
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Local Institution - 0027
NOT_YET_RECRUITINGSeongnam-si, Gyeonggi-do, 13496, South Korea
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Local Institution - 0031
NOT_YET_RECRUITINGCologne, North Rhine-Westphalia, 50937, Germany
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Local Institution - 0032
NOT_YET_RECRUITINGTaichung, 404332, Taiwan
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Local Institution - 0033
NOT_YET_RECRUITINGWestmead, New South Wales, 2145, Australia
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Local Institution - 0053
NOT_YET_RECRUITINGMetropolitan Borough of Wirral, CH63 4JY, United Kingdom
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Local Institution - 0070
NOT_YET_RECRUITINGLos Angeles, California, 90064, United States
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Local Institution - 0075
NOT_YET_RECRUITINGGuangzhou, Guangdong, 510515, China
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Local Institution - 0078
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, 200032, China
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Local Institution - 0083
NOT_YET_RECRUITINGSeattle, Washington, 98109-1024, United States
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Local Institution - 0086
NOT_YET_RECRUITINGXi'an, Shaanxi, 710126, China
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Local Institution - 0089
NOT_YET_RECRUITINGMilan, 20132, Italy
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Local Institution - 0095
NOT_YET_RECRUITINGMadrid, 28050, Spain
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Local Institution - 0100
NOT_YET_RECRUITINGMineola, New York, 11501, United States
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Local Institution - 0105
NOT_YET_RECRUITINGWarsaw, Masovian Voivodeship, 02-106, Poland
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Local Institution - 0107
NOT_YET_RECRUITINGChicago, Illinois, 60611, United States
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Local Institution - 0109
NOT_YET_RECRUITINGPisa, Tuscany, 56126, Italy
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Local Institution - 0114
NOT_YET_RECRUITINGBeijing, Beijing Municipality, 100036, China
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Local Institution - 0115
NOT_YET_RECRUITINGXi'an, Shaanxi, 710038, China
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Local Institution - 0116
NOT_YET_RECRUITINGFuzhou, Fujian, 350025, China
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Local Institution - 0118
NOT_YET_RECRUITINGJinan, Shandong, 250117, China
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Local Institution - 0119
NOT_YET_RECRUITINGNanjing, Jiangsu, 210008, China
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Local Institution - 0123
NOT_YET_RECRUITINGNanchang, Jiangxi, 330006, China
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Local Institution - 0125
NOT_YET_RECRUITINGChongqing, Chongqing Municipality, 400016, China
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Local Institution - 0126
NOT_YET_RECRUITINGHangzhou, Zhejiang, 310022, China
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Local Institution - 0128
NOT_YET_RECRUITINGNanyang, Henan, 473000, China
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Local Institution - 0130
NOT_YET_RECRUITINGHarbin, Heilongjiang, 150001, China
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Local Institution - 0134
NOT_YET_RECRUITINGDetroit, Michigan, 48202, United States
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Local Institution - 0137
NOT_YET_RECRUITINGDuarte, California, 91010, United States
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National Cheng Kung University Hospital
RECRUITINGTainan, 704, Taiwan
Contact Phone: •••-•••-••••
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National Taiwan University Hospital
RECRUITINGTaipei, 10002, Taiwan
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Pontifica Universidad Catolica De Chile
RECRUITINGSantiago Region Metropolitana, Santiago Metropolitan, 8330034, Chile
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Providence Portland Medical Center
RECRUITINGPortland, Oregon, 97213, United States
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Providence St. Vincent Medical Center
RECRUITINGPortland, Oregon, 97225, United States
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Royal Prince Alfred Hospital
RECRUITINGCamperdown, New South Wales, 2050, Australia
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Sunshine Coast University Hospital
RECRUITINGBirtinya, Queensland, 4575, Australia
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Taipei Veterans General Hospital
RECRUITINGTaipei, 11217, Taiwan
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Tennessee Oncology
RECRUITINGNashville, Tennessee, 37203, United States
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The Royal Melbourne Hospital
RECRUITINGParkville, Victoria, 3052, Australia
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Universitaetsklinikum Frankfurt
RECRUITINGFrankfurt, D-60590, Germany
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Universitatsklinikum Schleswig-Holstein
RECRUITINGLübeck, Schleswig-Holstein, 23538, Germany
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
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