New drug combo aims to shrink liver tumors in First-Line patients

NCT ID NCT07291076

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study tests a new drug called pumitamig, alone or with another drug (ipilimumab), in people with advanced liver cancer that cannot be removed by surgery. The trial includes 198 participants who have not had prior cancer treatment. The goal is to see if the drugs are safe and can shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pumitamig (a drug) and ipilimumab (an immunotherapy drug)
What this could lead to: If successful, this could provide a new treatment option for people with advanced liver cancer who have not had prior therapy.
What could go wrong: This is an early-phase trial (Phase 1/2) with a small number of participants, so the drugs may not work or could cause serious side effects. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATOCELLULAR CARCINOMA (HCC)

Contacts and locations

Locations

Bradfordhill
RECRUITING

Santiago, Santiago Metropolitan, 8420383, Chile
CHU Bordeaux Haut-Leveque
RECRUITING

Pessac, Aquitaine, 33600, France
Cancer Research UK - The Beatson Institute for Cancer Research (Cancer Research UK Beatson Laboratories)
RECRUITING

Glasgow, South Western Scotland, G611BD, United Kingdom
Centre Hospitalier Universitaire de Grenoble
RECRUITING

La Tronche, Auvergne-Rhône-Alpes, 38700, France
Hammersmith Hospital
RECRUITING

London, London, City of, W12 0HS, United Kingdom
Hospital General Universitario Gregorio Marañon
RECRUITING

Madrid, 28007, Spain
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
RECRUITING

Meldola, Emilia-Romagna, 47014, Italy
John Theurer Cancer Center at Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601-2191, United States
Local Institution - 0001
NOT_YET_RECRUITING

Montpellier, Languedoc-Roussillon, 34295, France
Local Institution - 0003
NOT_YET_RECRUITING

Bobigny, 93000, France
Local Institution - 0008
NOT_YET_RECRUITING

Kashiwa, 277-8577, Japan
Local Institution - 0009
NOT_YET_RECRUITING

Singapore, 119074, Singapore
Local Institution - 0011
NOT_YET_RECRUITING

Seoul, Seoul-teukbyeolsi, 05505, South Korea
Local Institution - 0012
NOT_YET_RECRUITING

Singapore, 169610, Singapore
Local Institution - 0013
NOT_YET_RECRUITING

Seoul, Seoul Teugbyeolsi, 06351, South Korea
Local Institution - 0014
NOT_YET_RECRUITING

Pamplona, Navarre, 31008, Spain
Local Institution - 0015
NOT_YET_RECRUITING

Barcelona, 8036, Spain
Local Institution - 0016
NOT_YET_RECRUITING

Pisa, 56126, Italy
Local Institution - 0017
NOT_YET_RECRUITING

Osakasayama-shi, Osaka, 5898511, Japan
Local Institution - 0018
NOT_YET_RECRUITING

Saint Priest En Jarez, Pays de la Loire Region, 42270, France
Local Institution - 0020
NOT_YET_RECRUITING

Gdansk, 80-952, Poland
Local Institution - 0021
NOT_YET_RECRUITING

Wroclaw, Lower Silesian Voivodeship, 53-439, Poland
Local Institution - 0026
NOT_YET_RECRUITING

Mainz, 55101, Germany
Local Institution - 0027
NOT_YET_RECRUITING

Seongnam-si, Gyeonggi-do, 13496, South Korea
Local Institution - 0031
NOT_YET_RECRUITING

Cologne, North Rhine-Westphalia, 50937, Germany
Local Institution - 0032
NOT_YET_RECRUITING

Taichung, 404332, Taiwan
Local Institution - 0033
NOT_YET_RECRUITING

Westmead, New South Wales, 2145, Australia
Local Institution - 0053
NOT_YET_RECRUITING

Metropolitan Borough of Wirral, CH63 4JY, United Kingdom
Local Institution - 0070
NOT_YET_RECRUITING

Los Angeles, California, 90064, United States
Local Institution - 0075
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510515, China
Local Institution - 0078
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Local Institution - 0083
NOT_YET_RECRUITING

Seattle, Washington, 98109-1024, United States
Local Institution - 0086
NOT_YET_RECRUITING

Xi'an, Shaanxi, 710126, China
Local Institution - 0089
NOT_YET_RECRUITING

Milan, 20132, Italy
Local Institution - 0095
NOT_YET_RECRUITING

Madrid, 28050, Spain
Local Institution - 0100
NOT_YET_RECRUITING

Mineola, New York, 11501, United States
Local Institution - 0105
NOT_YET_RECRUITING

Warsaw, Masovian Voivodeship, 02-106, Poland
Local Institution - 0107
NOT_YET_RECRUITING

Chicago, Illinois, 60611, United States
Local Institution - 0109
NOT_YET_RECRUITING

Pisa, Tuscany, 56126, Italy
Local Institution - 0114
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100036, China
Local Institution - 0115
WITHDRAWN

Xi'an, Shaanxi, 710038, China
Local Institution - 0116
NOT_YET_RECRUITING

Fuzhou, Fujian, 350028, China
Local Institution - 0118
NOT_YET_RECRUITING

Jinan, Shandong, 250117, China
Local Institution - 0119
NOT_YET_RECRUITING

Nanjing, Jiangsu, 210008, China
Local Institution - 0123
NOT_YET_RECRUITING

Nanchang, Jiangxi, 330006, China
Local Institution - 0125
NOT_YET_RECRUITING

Chongqing, Chongqing Municipality, 400016, China
Local Institution - 0126
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310022, China
Local Institution - 0128
NOT_YET_RECRUITING

Nanyang, Henan, 473000, China
Local Institution - 0130
NOT_YET_RECRUITING

Harbin, Heilongjiang, 150001, China
Local Institution - 0134
NOT_YET_RECRUITING

Detroit, Michigan, 48202, United States
Local Institution - 0137
NOT_YET_RECRUITING

Duarte, California, 91010, United States
National Cheng Kung University Hospital
RECRUITING

Tainan, 704, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
Pontifica Universidad Catolica De Chile
RECRUITING

Santiago Region Metropolitana, Santiago Metropolitan, 8330034, Chile
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States
Providence St. Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
Sunshine Coast University Hospital
RECRUITING

Birtinya, Queensland, 4575, Australia
Taipei Veterans General Hospital
RECRUITING

Taipei, 11217, Taiwan
Tennessee Oncology
RECRUITING

Nashville, Tennessee, 37203, United States
The Royal Melbourne Hospital
RECRUITING

Parkville, Victoria, 3052, Australia
Universitaetsklinikum Frankfurt
RECRUITING

Frankfurt, D-60590, Germany
Universitatsklinikum Schleswig-Holstein
RECRUITING

Lübeck, Schleswig-Holstein, 23538, Germany
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States

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