New heart zapping procedure takes on standard drugs in major AFib trial

NCT ID NCT06096337

Ongoing Disease control Sponsor: Boston Scientific Corporation Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a new, minimally invasive heart procedure called pulsed field ablation (PFA) works better and is safer than standard anti-arrhythmic drugs as the very first treatment for people with persistent atrial fibrillation (AFib). It will involve about 484 adults who have had continuous AFib for over a week but less than a year. The goal is to see if the one-time procedure is more effective at controlling the irregular heartbeat over 12 months compared to starting with daily medications.

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Contacts and locations

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Locations

AOU delle Marche - PO GM Lancisi

Ancona, AN, 60126, Italy
Arrhythmia Research Group

Jonesboro, Arkansas, 72401, United States
Aurora St. Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Banner University Medical Center Phoenix

Phoenix, Arizona, 85006, United States
Baptist Health Lexington

Lexington, Kentucky, 40503, United States
Bethesda North Hospital

Cincinnati, Ohio, 45242, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
CHU Grenoble - Hopital Michallon

Grenoble, 38043, France
Cardioangiologisches Centrum Bethanien

Frankfurt, 60431, Germany
Cardiology Associates Medical Group, Inc

Ventura, California, 93003, United States
Catholic Medical Center

Manchester, New Hampshire, 03102, United States
Centro Cardiologico Monzino

Milan, MI, 20138, Italy
Chippenham & Johnston-Willis Hospital (CJW)

Richmond, Virginia, 23225, United States
Christus Trinity Mother Frances Health System

Tyler, Texas, 75701, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Community Heart and Vascular Hospital

Indianapolis, Indiana, 46250, United States
Corewell Health

Grand Rapids, Michigan, 49503, United States
Emory University Hospital

Atlanta, Georgia, 30342, United States
Fondazione PTV - Policlinico Tor Vergata

Roma, 00133, Italy
Good Samaritan - Suffern

Suffern, New York, 10901, United States
HCA Florida Mercy Hospital

Miami, Florida, 33133, United States
Hamilton General Hospital

Hamilton, Ontario, L8L 2X2, Canada
Hospital Universitario La Fe

Valencia, Spain
Institut universitaire de Cardiologie et de Pneumologie de Quebec

Québec, Quebec, G1V 4G5, Canada
Intermountain Medical Center

Murray, Utah, 84107, United States
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
Kaleida Health

Buffalo, New York, 14203, United States
Klinicki Bolnicki Centar Split

Split, 21 000, Croatia
Maria Cecilia Hospital SPA

Cotignola, RA, 48010, Italy
Mayo Clinic Foundation-Hospital

Rochester, Minnesota, 55905, United States
Medizinische Univ.-Kliniken Graz-Hospital

Graz, 8036, Austria
Memorial Health University Medical Center

Savannah, Georgia, 31404, United States
Mercy Hospital Medical Center-Hospital

West Des Moines, Iowa, 50266, United States
Monash Medical Centre

Clayton, Victoria, 3168, Australia
National Heart Centre Singapore

Singapore, 169609, Singapore
Northwell Health

Bay Shore, New York, 11706, United States
OhioHealth Research and Innovation Institute - Riverside Methodist Hospital

Columbus, Ohio, 43214, United States
Oklahoma Heart Institute

Tulsa, Oklahoma, 74104, United States
Orion Medical

Houston, Texas, 77034, United States
Phoenix Cardiovascular Research Group

Phoenix, Arizona, 85018, United States
Prince of Wales Hospital

Shatin, 999077, Hong Kong
Queen Mary Hospital

Hong Kong, 999077, Hong Kong
Royal Adelaide Hospital-Hospital

Adelaide, South Australia, 5000, Australia
Sarasota Memorial Hospital

Sarasota, Florida, 34239, United States
Scripps Memorial Hosptial

La Jolla, California, 92037, United States
Southcoast Physicians Group

Fall River, Massachusetts, 02720, United States
St. Jan

Bruges, B-8000, Belgium
St. John's Hospital

Springfield, Illinois, 62701, United States
St. Joseph's Hospital

Tampa, Florida, 33614, United States
Staedtisches Klinikum Karlsruhe

Karlsruhe, 76133, Germany
Stanford University Medical Center

Palo Alto, California, 94305-5406, United States
Taipei Veterans General Hospital-Hospital

Taipei, 1127, Taiwan
Tallahassee Memorial Hospital

Tallahassee, Florida, 32308, United States
The Prince Charles Hospital

Chermside, Queensland, 4032, Australia
University of Alabama at Birmingham

Birmingham, Alabama, 35249-7333, United States
University of Michigan Hospitals

Ann Arbor, Michigan, 48108, United States
University of Texas Medical Branch

Galveston, Texas, 77555-0737, United States
Valley Hospital

Paramus, New Jersey, 07652, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Wake Forest University School of Medicine

Winston-Salem, North Carolina, 27157, United States
Weill Cornell Medical University

New York, New York, 10021, United States
York Hospital

York, Pennsylvania, 17403, United States

Conditions

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PERSISTENT ATRIAL FIBRILLATION