Can radiotherapy and poop pills outsmart liver cancer resistance?
NCT ID NCT07463248
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial tests whether adding personalized radiotherapy (PULSAR) and fecal microbiota transplants (FMT) to standard targeted-immunotherapy can reverse resistance in advanced liver cancer. About 64 patients whose cancer stopped responding to first-line treatment will be randomly assigned to either the new combo or a second-line drug switch. The goal is to see if this approach improves how long patients live without their cancer growing.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tislelizumab, tyrosine kinase inhibitors (lenvatinib, donafenib, apatinib, sorafenib, regorafenib), fecal microbiota transplantation, and personalized radiotherapy (PULSAR)
- What this could lead to
- If successful, this approach could offer a new way to overcome drug resistance in advanced liver cancer, potentially extending life for patients who stop responding to standard treatment.
- What could go wrong
- This is a small Phase 2 trial with only 64 participants, so results may not apply to all patients. The combination of treatments may cause side effects, and the benefit over standard second-line therapy is uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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West China Hospital
Chengdu, Sichuan, 610041, China
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