Could a tiny dose of magic mushrooms help teens stop Self-Harming?

NCT ID NCT06798636

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This early-phase study at Imperial College London is testing whether a low, non-hallucinogenic dose of psilocybin (the active ingredient in magic mushrooms) can make a mental imagery therapy more effective for young people aged 16-25 who self-harm. The therapy, called Imagery Re-Scripting, helps replace distressing mental images that drive self-harm with healthier ones. The study aims to see if psilocybin helps participants tolerate difficult emotions and become more open to change during therapy. Only 30 participants will be enrolled, and the focus is on understanding how the combination works, not yet on proving it as a treatment.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Psilocybin (5 mg oral dose)
What this could lead to
If successful, this could point toward a new treatment approach for self-harm in young people by combining low-dose psychedelics with cognitive therapy.
What could go wrong
This is a very early, small study (30 participants) focused on understanding mechanisms, not proving effectiveness. The low dose may not produce meaningful changes, and results may not generalize.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Self-Injurious Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Imperial College London

    RECRUITING

    London, United Kingdom

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Other studies related to the condition(s) this trial covers.