Magic mushroom compound tested as breakthrough for Hard-to-Treat depression

NCT ID NCT05711940

Summary

This large Phase 3 trial is testing whether two doses of a psilocybin-based therapy (COMP360), given with psychological support, can help adults with severe treatment-resistant depression. The study will compare different dose strengths to see which works best at reducing depression symptoms and improving daily functioning. It follows 572 participants for about a year to measure both the benefits and the safety of this experimental approach.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • A-Shine s.r.o.

    Pilsen, 30100, Czechia

  • APG Research, LLC- Advanced Psychiatric Group

    Orlando, Florida, 32803, United States

  • ASCLEPES Research Centers

    Thousand Oaks, California, 93012, United States

  • ATP Clinical Research, Inc.

    Orange, California, 92868, United States

  • Aalborg Universitetshospital-Psykiatrien Region Nordjylland

    Aalborg, 9000, Denmark

  • Abraham Cowley Unit - Surrey and Borders Partnership NHS Foundation Trust

    Chertsey, KT16 9AU, United Kingdom

  • Adams Clinical - Boston

    Watertown, Massachusetts, 02472, United States

  • Adams Clinical - Boston (Copley Clinical)

    Boston, Massachusetts, 02116, United States

  • Adams Clinical - New York

    New York, New York, 10029, United States

  • Adams Clinical - New York

    The Bronx, New York, 10461, United States

  • Alivation Research, LLC.

    Lincoln, Nebraska, 68526, United States

  • Atlanta Center for Medical Research

    Atlanta, Georgia, 30331, United States

  • Behavioral Clinical Research, Inc.

    Miami Lakes, Florida, 33016, United States

  • Bio Behavioral Health

    Toms River, New Jersey, 08755, United States

  • Brain Health Consultants and TMS Center

    Houston, Texas, 77046-2401, United States

  • CITrials

    Riverside, California, 92506, United States

  • CalNeuro Research Group, Inc

    Los Angeles, California, 90025, United States

  • Catalina Research Institute, LLC

    Montclair, California, 91763, United States

  • Cedar Clinical Research

    Draper, Utah, 84020, United States

  • Center for Depression Research and Clinical Care

    Dallas, Texas, 75247-9119, United States

  • Central Miami Medical Institute, LLC

    Miami, Florida, 33125, United States

  • Centre Hospitalier Sainte Anne - Clinique des Maladies Mentales et de l'Encephale (CMME)

    Paris, 75014, France

  • Centre Hospitalier Universitaire de Nimes (CHU) - Hopital Universitaire Caremeau

    Nîmes, 30000, France

  • Centre for Addiction and Mental Health (CAMH)

    Toronto, Ontario, Canada

  • Centre for Neurology Studies

    Vancouver, Canada

  • Centrum Badan Klinicznych PI-House Sp. z o.o.

    Gdansk, 80-546, Poland

  • Charite-Universitaetsmedizin Berlin

    Berlin, 12203, Germany

  • Chatham-Kent Clnical Trials Centre

    Chatham, Ontario, Canada

  • Clerkenwell Health

    London, W1G 8DR, United Kingdom

  • Cleveland Clinic - Lutheran Hospital

    Cleveland, Ohio, 44113-3108, United States

  • ClinSmart Sweden AB

    Solna, 17164, Sweden

  • Clinical Innovations, Inc.

    Bellflower, California, 90706, United States

  • Clinical Neurosciecne Solutions, Inc. dba CNS Healthcare

    Orlando, Florida, 32801, United States

  • Clinical Research Facility, Royal Devon and Exeter Hospital

    Exeter, EX2 5DW, United Kingdom

  • Cornwall Partnership NHS Foundation Trust

    Bodmin, Cornwall, PL31 2QT, United Kingdom

  • Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust - Wolfson Research Centre

    Newcastle, NE4 5PL, United Kingdom

  • Dent Neurosciences Research Center, Inc.

    Amherst, New York, 14226-1727, United States

  • Diex Recherche Sherbrooke Inc.

    Québec, B.C., J1L 0H8, Canada

  • FIDMAG Hermanas Hospitalarias

    Sant Boi de Llobregat, 08830, Spain

  • Fieve Clinical Research, Inc

    New York, New York, 10017, United States

  • Fulbourn Hospital - Cambridgeshire And Peterborough NHS Foundation Trust

    Fulbourn, CB21 5EF, United Kingdom

  • Ghu-Centre Hospitalier Sainte Anne, Centre de Recherche Clinique

    Paris, 75014, France

  • Grounded Research Hub - Rotherham Doncaster & South Humber NHS Foundation Trust

    Doncaster, DN4 8QN, United Kingdom

  • HCA Healthcare Research Institute - Medical City Green Oaks Hospital

    Plano, Texas, 75251, United States

  • Harvard Medical School - McLean Hospital

    Belmont, Massachusetts, 02478-1064, United States

  • Hassman Research Institute

    Berlin, New Jersey, 08009, United States

  • Health Synergy Clinical Research

    Okeechobee, Florida, 34972, United States

  • Health Synergy Clinical Research, LLC

    West Palm Beach, Florida, 33407, United States

  • Hospital Clinic de Barcelona

    Barcelona, 08036, Spain

  • Hospital Provincial de Zamora - Servicio de Psiquiatria

    Zamora, 49021, Spain

  • Hospital Universitario Fundacion Jimenez Diaz

    Madrid, 28040, Spain

  • Hospital Universitario Río Hortega de Valladolid

    Valladolid, 47012, Spain

  • Houston Clinical Trials, LLC

    Bellaire, Texas, 77401, United States

  • Hälsoklustret

    Stockholm, 11239, Sweden

  • Innovative Clinical Research, Inc.

    Lauderhill, Florida, 33319, United States

  • Institut Neuropsychiatricke Pece

    Prague, 18600, Czechia

  • Institute for Integrative Therapies

    Eden Prairie, Minnesota, 55347, United States

  • Johann Wolfgang Goethe-Universitaet Frankfurt am Main - Klinik fuer Psychiatrie, Psychosomatik und Psychotherapie

    Frankfurt, 60528, Germany

  • Kadima Neuropsychiatry Institute

    La Jolla, California, 92037, United States

  • King's College London - Institute of Psychiatry, Psychology

    London, SE5 8AF, United Kingdom

  • La Nua Day Hospital Mental Health Centre

    Galway, H91 VE03, Ireland

  • Leids Universitair Medisch Centrum (LUMC) (Leiden University Medical Center) - Leiden Institute for Brain and Cognition (LIBC)

    Leiden, 2300, Netherlands

  • Lighthouse Psychiatry Scottsdale

    Gilbert, Arizona, 85234, United States

  • Lumos Clinical Research Center

    San Jose, California, 95124, United States

  • Lunds Universitet - Medicinska Fakulteten (Lund University Faculty of Medicine)

    Lund, 22185, Sweden

  • M3 Wake Research

    Encino, California, 91316, United States

  • Medical Arts Health Research Centre, Kamloops

    Kamloops, British Columbia, Canada

  • Medical Arts Research Group

    Vancouver, Canada

  • Medical Arts Research Group - Penticton

    Penticton, British Columbia, V2A 5L5, Canada

  • Michigan Clinical Research Institute PC

    Ann Arbor, Michigan, 48105, United States

  • National Institute of Mental Health

    Klecany, 25067, Czechia

  • Neuroterapie KH Sro

    Kutná Hora, 28401, Czechia

  • New York State Psychiatric Institute

    New York, New York, 10032, United States

  • North Texas Clinical Trials

    Fort Worth, Texas, 76104, United States

  • Okanagan Clinical Trials

    Kelowna, British Columbia, V1Y 1Z9, Canada

  • Pacific Clinical Research Management Group, LLC

    Upland, California, 91786, United States

  • Parc Sanitari Sant Joan de Deu (Sant Joan de Deu Serveis de Salut Mental)

    Barcelona, 08830, Spain

  • Piedmont Hospital Neuroscience Centre

    Oakland, California, 94610, United States

  • Princeton Medical Institute

    Princeton, New Jersey, 08540, United States

  • Promente - Ośrodek Badań Klinicznych

    Bydgoszcz, 85-133, Poland

  • Psychedelicka klinika, s.r.o.

    Prague, 16300, Czechia

  • Psychiatric Ambulance

    Ostrava, 70868, Czechia

  • Psychiatric Medicine Associates

    Skokie, Illinois, 60076, United States

  • Relaro Medical Trials

    Dallas, Texas, 75243, United States

  • Richmond Behavioral Associates

    Staten Island, New York, 10312, United States

  • Rush University Medical Center

    Chicago, Illinois, 60612-3227, United States

  • Seattle Neuropsychiatric Treatment Center

    Seattle, Washington, 98104, United States

  • Sheffield Health and Social Care NHS Foundation Trust

    Sheffield, S10 3TH, United Kingdom

  • Spectrum Neuroscience and Treatment Institute

    New York, New York, 10021-4157, United States

  • St. Charles Psychiatric Associates - Midwest Research Group

    Saint Charles, Missouri, 63304, United States

  • St. Michael's Hospital

    Toronto, Ontario, M5B 1W8, Canada

  • St. Pancras Clinical Research

    Chester, CH2 1HX, United Kingdom

  • St. Pancras Clinical Research

    London, EC2Y 8EA, United Kingdom

  • Stanford University

    Stanford, California, 94305, United States

  • Stedman Clinical Trials

    Tampa, Florida, 33613, United States

  • Suburban Research Associates

    Media, Pennsylvania, 19063, United States

  • Syrentis Clinical Research

    Santa Ana, California, 92705, United States

  • Tallaght University Hospital

    Dublin, D24 NR0A, Ireland

  • The Ohio State University

    Columbus, Ohio, 43210, United States

  • The Regents of the University of California - San Diego

    La Jolla, California, 92037-1337, United States

  • The University of Texas at Austin - Dell Medical School

    Austin, Texas, 78712, United States

  • The University of Utah - Huntsman Mental Health Institute

    Salt Lake City, Utah, 84108, United States

  • The Warneford Hospital- NIHR Clinical Research Facility

    Oxford, OX3 7JX, United Kingdom

  • Universitair Medisch Centrum Utrecht (UMC Utrecht)

    Utrecht, 3584 CG, Netherlands

  • Universite Paris VI Pierre et Marie Curie - Hopital de La Salpetriere - Centre Emotion - USR 3246 (CNRS UMR 7593)

    Paris, 75013, France

  • University Medical Center Groningen

    Groningen, 9713 GZ, Netherlands

  • University Of Michigan Comprehensive Depression Center

    Ann Arbor, Michigan, 48109-2700, United States

  • University Of Nottingham/Nottinghamshire Healthcare Trust, Institute Of Mental Health

    Nottingham, NG7 2TU, United Kingdom

  • University South Florida

    Tampa, Florida, 33613-4788, United States

  • University of Cincinnati, Department of Psychiatry & Behavirol Neuroscience

    Cincinnati, Ohio, 45219, United States

  • University of Massachusetts Medical School

    North Worcester, Massachusetts, 01655, United States

  • Uniwersyteckle Centrum Kliniczne, Klinika Psychiatrii Doroslych

    Gdansk, 80-214, Poland

  • Uptown Research Institute, LLC

    Chicago, Illinois, 60640, United States

  • Vuxenpsykiatrimottagningen

    Landskrona, 26153, Sweden

  • ZiP Campus Luebeck

    Lübeck, 23562, Germany

  • iResearch Atlanta

    Decatur, Georgia, 30030, United States

Conditions

Explore the condition pages connected to this study.