Magic mushroom compound tested as breakthrough for Hard-to-Treat depression
NCT ID NCT05711940
Summary
This large Phase 3 trial is testing whether two doses of a psilocybin-based therapy (COMP360), given with psychological support, can help adults with severe treatment-resistant depression. The study will compare different dose strengths to see which works best at reducing depression symptoms and improving daily functioning. It follows 572 participants for about a year to measure both the benefits and the safety of this experimental approach.
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Contacts and locations
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Locations
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A-Shine s.r.o.
Pilsen, 30100, Czechia
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APG Research, LLC- Advanced Psychiatric Group
Orlando, Florida, 32803, United States
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ASCLEPES Research Centers
Thousand Oaks, California, 93012, United States
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ATP Clinical Research, Inc.
Orange, California, 92868, United States
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Aalborg Universitetshospital-Psykiatrien Region Nordjylland
Aalborg, 9000, Denmark
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Abraham Cowley Unit - Surrey and Borders Partnership NHS Foundation Trust
Chertsey, KT16 9AU, United Kingdom
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Adams Clinical - Boston
Watertown, Massachusetts, 02472, United States
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Adams Clinical - Boston (Copley Clinical)
Boston, Massachusetts, 02116, United States
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Adams Clinical - New York
New York, New York, 10029, United States
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Adams Clinical - New York
The Bronx, New York, 10461, United States
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Alivation Research, LLC.
Lincoln, Nebraska, 68526, United States
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Atlanta Center for Medical Research
Atlanta, Georgia, 30331, United States
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Behavioral Clinical Research, Inc.
Miami Lakes, Florida, 33016, United States
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Bio Behavioral Health
Toms River, New Jersey, 08755, United States
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Brain Health Consultants and TMS Center
Houston, Texas, 77046-2401, United States
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CITrials
Riverside, California, 92506, United States
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CalNeuro Research Group, Inc
Los Angeles, California, 90025, United States
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Catalina Research Institute, LLC
Montclair, California, 91763, United States
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Cedar Clinical Research
Draper, Utah, 84020, United States
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Center for Depression Research and Clinical Care
Dallas, Texas, 75247-9119, United States
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Central Miami Medical Institute, LLC
Miami, Florida, 33125, United States
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Centre Hospitalier Sainte Anne - Clinique des Maladies Mentales et de l'Encephale (CMME)
Paris, 75014, France
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Centre Hospitalier Universitaire de Nimes (CHU) - Hopital Universitaire Caremeau
Nîmes, 30000, France
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Centre for Addiction and Mental Health (CAMH)
Toronto, Ontario, Canada
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Centre for Neurology Studies
Vancouver, Canada
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Centrum Badan Klinicznych PI-House Sp. z o.o.
Gdansk, 80-546, Poland
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Charite-Universitaetsmedizin Berlin
Berlin, 12203, Germany
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Chatham-Kent Clnical Trials Centre
Chatham, Ontario, Canada
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Clerkenwell Health
London, W1G 8DR, United Kingdom
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Cleveland Clinic - Lutheran Hospital
Cleveland, Ohio, 44113-3108, United States
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ClinSmart Sweden AB
Solna, 17164, Sweden
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Clinical Innovations, Inc.
Bellflower, California, 90706, United States
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Clinical Neurosciecne Solutions, Inc. dba CNS Healthcare
Orlando, Florida, 32801, United States
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Clinical Research Facility, Royal Devon and Exeter Hospital
Exeter, EX2 5DW, United Kingdom
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Cornwall Partnership NHS Foundation Trust
Bodmin, Cornwall, PL31 2QT, United Kingdom
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Cumbria, Northumberland, Tyne and Wear NHS Foundation Trust - Wolfson Research Centre
Newcastle, NE4 5PL, United Kingdom
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Dent Neurosciences Research Center, Inc.
Amherst, New York, 14226-1727, United States
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Diex Recherche Sherbrooke Inc.
Québec, B.C., J1L 0H8, Canada
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FIDMAG Hermanas Hospitalarias
Sant Boi de Llobregat, 08830, Spain
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Fieve Clinical Research, Inc
New York, New York, 10017, United States
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Fulbourn Hospital - Cambridgeshire And Peterborough NHS Foundation Trust
Fulbourn, CB21 5EF, United Kingdom
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Ghu-Centre Hospitalier Sainte Anne, Centre de Recherche Clinique
Paris, 75014, France
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Grounded Research Hub - Rotherham Doncaster & South Humber NHS Foundation Trust
Doncaster, DN4 8QN, United Kingdom
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HCA Healthcare Research Institute - Medical City Green Oaks Hospital
Plano, Texas, 75251, United States
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Harvard Medical School - McLean Hospital
Belmont, Massachusetts, 02478-1064, United States
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Hassman Research Institute
Berlin, New Jersey, 08009, United States
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Health Synergy Clinical Research
Okeechobee, Florida, 34972, United States
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Health Synergy Clinical Research, LLC
West Palm Beach, Florida, 33407, United States
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Hospital Clinic de Barcelona
Barcelona, 08036, Spain
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Hospital Provincial de Zamora - Servicio de Psiquiatria
Zamora, 49021, Spain
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Hospital Universitario Fundacion Jimenez Diaz
Madrid, 28040, Spain
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Hospital Universitario Río Hortega de Valladolid
Valladolid, 47012, Spain
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Houston Clinical Trials, LLC
Bellaire, Texas, 77401, United States
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Hälsoklustret
Stockholm, 11239, Sweden
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Innovative Clinical Research, Inc.
Lauderhill, Florida, 33319, United States
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Institut Neuropsychiatricke Pece
Prague, 18600, Czechia
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Institute for Integrative Therapies
Eden Prairie, Minnesota, 55347, United States
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Johann Wolfgang Goethe-Universitaet Frankfurt am Main - Klinik fuer Psychiatrie, Psychosomatik und Psychotherapie
Frankfurt, 60528, Germany
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Kadima Neuropsychiatry Institute
La Jolla, California, 92037, United States
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King's College London - Institute of Psychiatry, Psychology
London, SE5 8AF, United Kingdom
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La Nua Day Hospital Mental Health Centre
Galway, H91 VE03, Ireland
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Leids Universitair Medisch Centrum (LUMC) (Leiden University Medical Center) - Leiden Institute for Brain and Cognition (LIBC)
Leiden, 2300, Netherlands
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Lighthouse Psychiatry Scottsdale
Gilbert, Arizona, 85234, United States
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Lumos Clinical Research Center
San Jose, California, 95124, United States
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Lunds Universitet - Medicinska Fakulteten (Lund University Faculty of Medicine)
Lund, 22185, Sweden
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M3 Wake Research
Encino, California, 91316, United States
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Medical Arts Health Research Centre, Kamloops
Kamloops, British Columbia, Canada
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Medical Arts Research Group
Vancouver, Canada
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Medical Arts Research Group - Penticton
Penticton, British Columbia, V2A 5L5, Canada
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Michigan Clinical Research Institute PC
Ann Arbor, Michigan, 48105, United States
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National Institute of Mental Health
Klecany, 25067, Czechia
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Neuroterapie KH Sro
Kutná Hora, 28401, Czechia
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New York State Psychiatric Institute
New York, New York, 10032, United States
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North Texas Clinical Trials
Fort Worth, Texas, 76104, United States
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Okanagan Clinical Trials
Kelowna, British Columbia, V1Y 1Z9, Canada
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Pacific Clinical Research Management Group, LLC
Upland, California, 91786, United States
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Parc Sanitari Sant Joan de Deu (Sant Joan de Deu Serveis de Salut Mental)
Barcelona, 08830, Spain
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Piedmont Hospital Neuroscience Centre
Oakland, California, 94610, United States
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Princeton Medical Institute
Princeton, New Jersey, 08540, United States
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Promente - Ośrodek Badań Klinicznych
Bydgoszcz, 85-133, Poland
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Psychedelicka klinika, s.r.o.
Prague, 16300, Czechia
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Psychiatric Ambulance
Ostrava, 70868, Czechia
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Psychiatric Medicine Associates
Skokie, Illinois, 60076, United States
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Relaro Medical Trials
Dallas, Texas, 75243, United States
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Richmond Behavioral Associates
Staten Island, New York, 10312, United States
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Rush University Medical Center
Chicago, Illinois, 60612-3227, United States
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Seattle Neuropsychiatric Treatment Center
Seattle, Washington, 98104, United States
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Sheffield Health and Social Care NHS Foundation Trust
Sheffield, S10 3TH, United Kingdom
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Spectrum Neuroscience and Treatment Institute
New York, New York, 10021-4157, United States
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St. Charles Psychiatric Associates - Midwest Research Group
Saint Charles, Missouri, 63304, United States
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St. Michael's Hospital
Toronto, Ontario, M5B 1W8, Canada
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St. Pancras Clinical Research
Chester, CH2 1HX, United Kingdom
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St. Pancras Clinical Research
London, EC2Y 8EA, United Kingdom
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Stanford University
Stanford, California, 94305, United States
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Stedman Clinical Trials
Tampa, Florida, 33613, United States
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Suburban Research Associates
Media, Pennsylvania, 19063, United States
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Syrentis Clinical Research
Santa Ana, California, 92705, United States
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Tallaght University Hospital
Dublin, D24 NR0A, Ireland
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The Ohio State University
Columbus, Ohio, 43210, United States
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The Regents of the University of California - San Diego
La Jolla, California, 92037-1337, United States
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The University of Texas at Austin - Dell Medical School
Austin, Texas, 78712, United States
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The University of Utah - Huntsman Mental Health Institute
Salt Lake City, Utah, 84108, United States
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The Warneford Hospital- NIHR Clinical Research Facility
Oxford, OX3 7JX, United Kingdom
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Universitair Medisch Centrum Utrecht (UMC Utrecht)
Utrecht, 3584 CG, Netherlands
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Universite Paris VI Pierre et Marie Curie - Hopital de La Salpetriere - Centre Emotion - USR 3246 (CNRS UMR 7593)
Paris, 75013, France
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University Medical Center Groningen
Groningen, 9713 GZ, Netherlands
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University Of Michigan Comprehensive Depression Center
Ann Arbor, Michigan, 48109-2700, United States
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University Of Nottingham/Nottinghamshire Healthcare Trust, Institute Of Mental Health
Nottingham, NG7 2TU, United Kingdom
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University South Florida
Tampa, Florida, 33613-4788, United States
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University of Cincinnati, Department of Psychiatry & Behavirol Neuroscience
Cincinnati, Ohio, 45219, United States
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University of Massachusetts Medical School
North Worcester, Massachusetts, 01655, United States
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Uniwersyteckle Centrum Kliniczne, Klinika Psychiatrii Doroslych
Gdansk, 80-214, Poland
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Uptown Research Institute, LLC
Chicago, Illinois, 60640, United States
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Vuxenpsykiatrimottagningen
Landskrona, 26153, Sweden
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ZiP Campus Luebeck
Lübeck, 23562, Germany
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iResearch Atlanta
Decatur, Georgia, 30030, United States
Conditions
Explore the condition pages connected to this study.