Magic mushroom compound tested as potential breakthrough for severe depression

NCT ID NCT05624268

Summary

This large, late-stage trial is testing whether a single dose of a psilocybin-based therapy (COMP360), given with psychological support, can reduce symptoms in people with treatment-resistant depression. About 255 participants will be randomly assigned to receive either the active treatment or a placebo. The main goal is to see if the treatment is effective and safe over six weeks, with longer-term follow-up to check if benefits last.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • APG Research, LLC

    Orlando, Florida, 32803, United States

  • ASCLEPES Research Centers

    Thousand Oaks, California, 93012, United States

  • ATP Clinical Research, Inc.

    Orange, California, 92868, United States

  • Alivation Research, LLC.

    Lincoln, Nebraska, 68526, United States

  • Artemis Institute for Clinical Research

    San Diego, California, 92103, United States

  • Bio Behavioral Health

    Toms River, New Jersey, 08755, United States

  • CBH Health, LLC

    Gaithersburg, Maryland, 20877, United States

  • CalNeuro Research Group, Inc

    Los Angeles, California, 90025, United States

  • California Center for Psychedelic Therapy

    Los Angeles, California, 90004, United States

  • Cedar Clinical Research

    Draper, Utah, 84020, United States

  • Clarity Clinical Research, LLC

    Los Angeles, California, 90064, United States

  • Clinical Neurosciecne Solutions, Inc. dba CNS Healthcare

    Orlando, Florida, 32801, United States

  • Collaborative Neuroscience Network, LLC

    Garden Grove, California, 92845, United States

  • Comprehensive Psychiatric Care

    Norwich, Connecticut, 06360, United States

  • Core Clinical Research

    Everett, Washington, 98201, United States

  • DMI Health Care Group, Inc

    Tampa, Florida, 33782, United States

  • Emory University

    Atlanta, Georgia, 30329-2209, United States

  • Global Medical Institutes, LLC, Scranton Medical Institute

    Moosic, Pennsylvania, 18507, United States

  • Insight Clinical Trials, LLC

    Beachwood, Ohio, 44122, United States

  • Kadima Neuropsychiatry Institute

    La Jolla, California, 92037, United States

  • Lumos Clinical Research Center

    San Jose, California, 95124, United States

  • Meridien Research/Accel Research

    Tampa, Florida, 33803, United States

  • Midwest Research Group

    Saint Charles, Missouri, 63304, United States

  • Neuro-Behaviroral Clinical Research, Inc.

    North Canton, Ohio, 44720, United States

  • New York State Psychiatric Institute

    New York, New York, 10032, United States

  • Pharmasite Research, Inc

    Pikesville, Maryland, 21208, United States

  • ProScience Research Group

    Culver City, California, 90230, United States

  • Psych Atlanta

    Atlanta, Georgia, 30060, United States

  • Rivus Wellness & Research Institute

    Oklahoma City, Oklahoma, 73112, United States

  • Sheppard Pratt Health System

    Baltimore, Maryland, 21044, United States

  • Stanford University

    Stanford, California, 94305, United States

  • The Medical Research Network, LLC

    New York, New York, 10128, United States

  • UT Health Science Center at Houston (UTHSC-H)

    Houston, Texas, 77030, United States

  • University California San Diego

    La Jolla, California, 92037, United States

  • University of Arizona College of Medicine - Tuscon

    Tucson, Arizona, 85724, United States

  • University of Massachusetts Medical School

    North Worcester, Massachusetts, 01655, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55416, United States

  • University of Missouri

    Columbia, Missouri, 65212, United States

  • Uptown Research Institute, LLC

    Chicago, Illinois, 60640, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.