Magic mushroom therapy shows promise for depression in small trial
NCT ID NCT05227612
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tested whether combining psilocybin (the active ingredient in magic mushrooms) with cognitive behavioral therapy is a feasible and acceptable treatment for major depression. Sixteen adults with moderate to severe depression received two doses of psilocybin plus 12 therapy sessions. The goal was to see if people would stick with the treatment and find it helpful, not to prove it works yet.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Locations
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UCLA Semel Institute
Los Angeles, California, 90095, United States