Could a simple blood injection revive aging ovaries?
NCT ID NCT04278313
First seen Jun 27, 2026 ยท Last updated Jun 27, 2026
Summary
This study tests whether injecting a woman's own platelet-rich plasma (PRP) into her ovaries can improve egg quality and IVF success. About 90 women with low ovarian reserve (due to age or other causes) will receive either PRP or a placebo injection. The main goal is to see if more usable embryos can be produced for fertility treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 90 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2020
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 to 44 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * fewer than 6 oocytes in response to past ovulation induction * desire to establish a pregnancy using IVF * Age 44 years and under. * FSH \> 12 * AMH \< 1.0 * No Aspirin or Motrin for one week before treatment Exclusion Criteria: * Age \> 45 years * Marked thrombocytopenia * Blood diseases * Hypofibrinogenemia * Hemodynamic instability * Anticoagulant or antiaggregant treatment * Oncological diseases (specially, skeletal system and blood) * Sepsis * Acute and chronic infectious diseases * Autoimmune diseases, for example, lupus erythematosus, etc.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Center for Human Reproduction
New York, New York, 10021, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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