Proton vs X-Ray: which prostate radiation causes fewer side effects?

NCT ID NCT01617161

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 29 times

Summary

This study compares two types of radiation therapy—proton beam therapy and IMRT—for men with low- or intermediate-risk prostate cancer. Both treatments aim to cure the cancer by targeting the prostate while sparing healthy tissue, but they may cause different side effects like bowel, urinary, or erectile problems. Researchers are following 454 men to see which therapy leads to better quality of life two years after treatment.

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Contacts and locations

Locations

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Mass General/North Shore Cancer Center

    Danvers, Massachusetts, 01923, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Northwestern Medicine Chicago Proton Center

    Chicago, Illinois, 60190, United States

  • Princeton ProCure Proton Therapy Center

    Somerset, New Jersey, 08873, United States

  • Provision Proton Therapy Center

    Knoxville, Tennessee, 37909, United States

  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey, 08903, United States

  • University Hospital of Cleveland

    Cleveland, Ohio, 44106, United States

  • University of Florida Health Proton Therapy Institute

    Jacksonville, Florida, 32206, United States

  • University of Maryland Medical Center

    College Park, Maryland, 20742, United States

  • University of Washington Medical Center

    Seattle, Washington, 98195, United States

  • Washington University

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.