Hemophilia a study observes how new patients respond to factor VIII in daily practice

NCT ID NCT03695978

Recruiting now Knowledge-focused Sponsor: Octapharma Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is observing how well three Factor VIII concentrates (Nuwiq, Octanate, Wilate) work in real-world settings for people with severe hemophilia A who have had little or no prior treatment. Researchers will track bleeding rates and side effects in about 200 participants of any age. The goal is to understand how these treatments perform outside of controlled clinical trials.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Factor VIII concentrates (Nuwiq, Octanate, Wilate)
What this could lead to: If successful, this study could provide real-world data on how well these FVIII concentrates work and their safety in young, untreated hemophilia A patients.
What could go wrong: This is an observational study, not a controlled trial, so results may be influenced by factors other than the treatment. It does not test a new drug, but rather gathers routine clinical data.

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Conditions

The condition(s) this trial relates to.

hemophilia A severe hemophilia A

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HAEMOPHILIA A

Contacts and locations

Locations

Azerbaijan State Advanced Training Institute for Doctors Hematology Department Scientific-Research Center of Hemophilia
WITHDRAWN

Baku, AZ1012, Azerbaijan
Azienda Ospedaliera-Universitaria Policlinico "Vittorio Emanuele", Centro di Riferimento Regionale per la Prevenzione, Diagnosi e Cura delle Malattie Rare della Coagulazione nel Bambino e neel'Adulto. U.O.C Ematologia con trapianto di Midollo Osseo
RECRUITING

Catania, 95123, Italy
Azienda Ospedaliero Universitaria Careggi
RECRUITING

Florence, 50134, Italy
Birmingham Children's Hospital NHS Foundation Trust
WITHDRAWN

Birmingham, B46NH, United Kingdom
C.tro Emofilia A.O. Città della salute e della scienza di Torino, Ospedale Regina Margherita
RECRUITING

Torino, Italy
CENIDOR
ACTIVE_NOT_RECRUITING

Salta, Argentina
CENTRE HOSPITALIER UNIVERSITAIRE de BESANCON
RECRUITING

Besançon, France
CHRU Hopital Nord, Secretariat de pediatre, bat E niv +3
RECRUITING

Saint-Priest-en-Jarez, 42270, France
CHRU Tours - Hôpital Trousseau
RECRUITING

Chambray-lès-Tours, France
CHU Hotel Dieu, Centre de Traitment de l'Hemophilie
RECRUITING

Nantes, 44093, France
Center for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital
RECRUITING

Milan, Italy
Centre Régional de Traitement de l'hémophilie
RECRUITING

Le Mans, France
Centro Emofilia - AUO di Padova
WITHDRAWN

Padova, Italy
Children's Hospital Affiliate of Vilnius Universtity Hospital Santaros Klinikos
RECRUITING

Vilnius, LT-08406, Lithuania
Cliniques Universitaires Saint-Luc
RECRUITING

Brussels, 1200, Belgium
Cliniques Universitaires Saint-Luc
RECRUITING

Brussels, 1200, Belgium
Coagulation Research Centre GmbH
RECRUITING

Duisburg, 47051, Germany
Cure 4 The Kids Foundation Children's Specialty Center
WITHDRAWN

Las Vegas, Nevada, 89109, United States
Department of Hematology Research Research Transition Facility
COMPLETED

Edmonton, T6G 2V2, Canada
Great Ormond Street Hospital for Children NHS Trust, Haemophilia Centre
RECRUITING

London, WC1N 3JH, United Kingdom
HRU Malaga
NOT_YET_RECRUITING

Málaga, Spain
HZRM GmbH
ACTIVE_NOT_RECRUITING

Frankfurt, Germany
Heim Pál National Pediatric Institute Department of Oncology and Hematology
RECRUITING

Budapest, 1089, Hungary
Hopital Simone Veil Groupement Hospitalier Eaubonne-Montmorency
RECRUITING

Montmorency, 95160, France
Hospital General Universitario de Alicante Hematología y Hemoterapia
RECRUITING

Alicante, 03010, Spain
Hospital General de Occidente, Unidad de Hemato-Oncologia Pediatric, Av. Zoquipan 1050, Col Seattle, , Col Seattle
RECRUITING

Jalisco, Mexico
Hospital Infantil de Morelia Eva Sámano de López Mateos
NOT_YET_RECRUITING

Morelia, Mexico
Hospital Universitari Vall D'Hebrón, Unitat d'Hemofilia
RECRUITING

Barcelona, 02035, Spain
Hospital Universitario Dr. José Eleuterio Gonzalez S/N
NOT_YET_RECRUITING

Nuevo León, Mexico
Hospital Universitario y Politécnico La Fe
ACTIVE_NOT_RECRUITING

Valencia, Spain
Hôpital Universitaire des Enfants Reine Fabiola
RECRUITING

Brussels, 1020, Belgium
Hôspital Necker Enfants Malades
RECRUITING

Paris, France
Institute of Experimental Haematology and Transfusion Medicine (IHT) University Clinic Bonn (AöR)
RECRUITING

Bonn, 53127, Germany
Istanbul University Faculty of Medicine
WITHDRAWN

Fatih, Turkey (Türkiye)
John Radcliffe Hospital, Oxford University Hospitals, NHS Foundation Trust
RECRUITING

Headington, Oxford, OX3 9DU, United Kingdom
McMaster University, Division of Pediatric Hematology/Oncology Room 3N27
WITHDRAWN

Hamilton, Ontario, 1800NOCLOTS, Canada
Moscow State Government-financed Public Healthcare Institution "Morozovskaya Children Clinical Hospital of Moscow Healthcare Department"
WITHDRAWN

Moscow, 119049, Russia
Newcastle Haemophilia Comprehensive Care Centre, Royal Victoria Infirmary
RECRUITING

Newcastle upon Tyne, NE1 4LP, United Kingdom
Ochsner Clinic Foundation
ACTIVE_NOT_RECRUITING

New Orleans, Louisiana, 70121, United States
Ospedale Maggiore Policlinico
RECRUITING

Milan, 920122, Italy
Ospedale Pediatrico "Giovani XXIII"
RECRUITING

Bari, Italy
Ospedale Regina Margherita
WITHDRAWN

Turin, 10126, Italy
Ospedale San Giacomo
COMPLETED

Castelfranco Veneto, 31033, Italy
Policlinico Sant'Orsola Malpighi
RECRUITING

Bologna, 40138, Italy
Policlinico Umberto I
RECRUITING

Rome, 00161, Italy
Republican Scientific Center for Radiation Medicine and Human Ecology
WITHDRAWN

Homyel, 246040, Belarus
Republican Scientific and Practical Centre of Children Oncology, Hematology and Immunology
RECRUITING

Minsk, 223053, Belarus
SMO and Scientific Services S.A.P.P de C.V
NOT_YET_RECRUITING

Nuevo León, Mexico
Saint-Petersburg State Budget Healthcare Institution "City Out-patient Clinical # 37"
WITHDRAWN

Saint Petersburg, 191186, Russia
St. Louis University , 221 North Grand Boulevard
NOT_YET_RECRUITING

St Louis, Missouri, 63103, United States
Tallinn Childrenś Hospital Clinic of Paediatric Department of Haematology and Oncology
WITHDRAWN

Tallinn, 13419, Estonia
The Centre Hospitalier Métropole Savoie
RECRUITING

Chambéry, 31125 73011, France
The University of Texas Health Science Center at San Antonio
NOT_YET_RECRUITING

San Antonio, Texas, 78712, United States
Universitary Hospital Son Espases (Hematology Service)
ACTIVE_NOT_RECRUITING

Palma de Mallorca, Spain
University Hospital Centre Zagreb
RECRUITING

Zagreb, Croatia
University Hospital Essen
ACTIVE_NOT_RECRUITING

Essen, Germany
University of Debrecen Department of Pediatrics
RECRUITING

Debrecen, 4032, Hungary
University of Miami Miller School of Medicine
RECRUITING

Miami, Florida, 33136, United States
Vivantes - Netzwerk für Gesundheit GmbH Klinikum im Friedrichshain
ACTIVE_NOT_RECRUITING

Berlin, 10249, Germany

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