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Why IVF hormone levels in blood may not match the womb

NCT ID NCT07818278

Knowledge-focused Sponsor: University Hospital, Ghent Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers are studying how progesterone levels in the womb lining vary from one treatment cycle to the next in women preparing for a frozen embryo transfer after IVF. Participants go through two practice cycles with estrogen and progesterone, then their real transfer cycle. The study collects blood, urine, tissue, swabs, and ultrasound recordings to see how hormones relate to womb contractions, bacteria, and tiny cell particles. The goal is to learn whether checking womb hormone levels could help doctors personalize treatment and improve pregnancy chances.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Estradiol gel and progesterone vaginal capsules used to prepare the womb lining for frozen embryo transfer
What this could lead to
If researchers learn how progesterone levels in the womb lining vary, doctors could tailor hormone doses for frozen embryo transfers and potentially improve pregnancy success.
What could go wrong
This small study measures hormones and bacteria; it does not test whether changing treatment improves pregnancy rates. The findings may not apply to all IVF patients or lead to better outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 70 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Aug 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 and ≤40 years old. * BMI ≥ 18 kg/m² and \< 35 kg/m². * Current pregnancy wish. * PGT-A tested patients, undergoing a euploid blastocyst transfer in an artificial cycle. * Dutch, French and/or English speakers, as informed consent forms (ICFs) are made in those three languages. Exclusion Criteria: * Known reasons for impaired implantation (specifically: presence of a hydrosalpinx; presence of a type I, II or III fibroid; Asherman's syndrome; uterine malformations; intrauterine adhesions; ≥ grade 3 endometriosis according to the ASRM classification, endometrial tuberculosis, adenomyosis). * Abnormal (not menstrual) vaginal bleeding without a known/diagnosed cause. * Tumours of the ovary, breast, uterus, pituitary or hypothalamus. * Untreated and uncontrolled thyroid dysfunction. * Personal history of a thromboembolic event. * Use of carbamazepine, rifampicin, phenytoin. * Subjects unable to comprehend the investigational nature of the proposed study. * Patients with a history of known thin endometrium (\< 5 mm).

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fertility Implantation, embryo

How to take part

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  1. The places running it

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  2. The official record

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Contacts and locations

Locations

  • Ghent University Hospital

    Ghent, 9000, Belgium

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