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Gut health hack: probiotics may supercharge psoriasis drug

NCT ID NCT07169019

Recruiting now Disease control Sponsor: Alexandria University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This early-stage study tests whether adding daily probiotics to weekly methotrexate can improve psoriasis symptoms and gut bacteria in newly diagnosed adults. 24 participants will either get probiotics plus methotrexate or methotrexate alone for 4 months. Researchers will compare changes in skin severity and stool samples to see if the combination works better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
probiotics and methotrexate
What this could lead to
If it works, this could point toward a simple, low-cost way to boost the effectiveness of standard psoriasis treatment by improving gut health.
What could go wrong
This is a very early, small pilot study with only 24 people. The results may not apply to everyone, and the combination might not work better than methotrexate alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PSORIASIS (PSO)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Medical Research Institute, Alexandria University

    RECRUITING

    Alexandria, 21561, Egypt

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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