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Probiotics after antibiotics: a gut check

NCT ID NCT07425704

Knowledge-focused Sponsor: Cultech Ltd Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether taking probiotics after a course of antibiotics can help restore the natural balance of bacteria in the gut. Fifty adults aged 18-40 who are prescribed a cephalosporin antibiotic will take either a probiotic supplement or a placebo for several weeks. Researchers will analyze stool and vaginal samples to see how the microbiome changes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Probiotic (Lab4S) containing lactic acid bacteria and Saccharomyces boulardii
What this could lead to
If it works, this could show that taking probiotics after antibiotics helps restore a healthy gut microbiome.
What could go wrong
This is a small, early-stage study with only 50 people. It may not prove probiotics are effective, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults, aged 18-40. 2. Been prescribed an oral dose of cephalosporin antibiotic lasting 5 - 10 days. 3. Willing to provide stool samples and, for women, vaginal samples. 4. Willing to avoid consumption of any other probiotic capsules/tablets during the study. Exclusion Criteria: 1. If antibiotics prescribed are intended to treat any gastrointestinal or vaginally related issue. 2. Any antibiotic intake within the last 3 months. 3. Immunodeficient or undergoing immunosuppressive therapy. 4. Currently diagnosed with diabetes/cardiovascular disease/cancer/dementia. 5. Any unexplained loss of weight in recent months. 6. Known to be pregnant or \<3 months postpartum.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Microbiome Probiotic

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

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  3. A doctor treating you

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Contacts and locations

Locations

  • Comac Medical

    Sofia, Bulgaria

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