Could a probiotic tame rheumatoid arthritis? early trial begins

NCT ID NCT05961592

Recruiting now Disease control Sponsor: Rise Therapeutics LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study is testing whether an oral probiotic called R-2487 is safe for people with rheumatoid arthritis. Researchers will also check if it reduces joint swelling and inflammation. The trial involves 73 adults with active RA who will take the probiotic and be monitored for side effects and changes in their disease activity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Probiotic (R-2487)
What this could lead to: If it works, this could point toward a new, gentle treatment option for rheumatoid arthritis that uses a probiotic instead of strong drugs.
What could go wrong: This is a very early Phase 1 trial with only 73 people, focused on safety. It is too soon to know if the probiotic will actually help arthritis symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTHRITIS, RHEUMATOID

Contacts and locations

Locations

AP Medical Research
RECRUITING

Miami, Florida, 33165, United States
Altoona Center for Research
RECRUITING

Duncansville, Pennsylvania, 16635, United States
Edward Jenner Research
RECRUITING

Plantation, Florida, 33317, United States
Prolato Clinical Research Center
RECRUITING

Houston, Texas, 77054, United States
St.Jude Clinical Research
RECRUITING

Doral, Florida, 33172, United States
University of California, San Diego
RECRUITING

San Diego, California, 92037, United States

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