Could two drugs stop surgery pain from backfiring?

NCT ID NCT01594047

Summary

This study tested whether giving the drugs ketamine during surgery and methadone after surgery could prevent a common problem: strong painkillers (opioids) sometimes make patients more sensitive to pain around their surgical wound. Researchers enrolled 113 patients having abdominal surgery to see if this two-drug approach reduced pain sensitivity and lowered overall painkiller use after the operation.

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Contacts and locations

Locations

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan, 20133, Italy

Conditions

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