Kidney shield drug trial halted early – what it means for heart surgery patients

NCT ID NCT06602453

First seen Nov 01, 2025 · Last updated May 06, 2026 · Updated 17 times

Summary

This study tested whether the drug GDC-8264 could prevent acute kidney injury and serious kidney problems in people having heart surgery. About 67 participants at moderate to high risk were enrolled, but the trial was stopped early. The goal was to see if the drug worked better than a placebo at protecting kidney function after surgery.

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Contacts and locations

Locations

  • APHP - Hopital de la Pitie Salpetriere

    Paris, 75013, France

  • Auckland City Hospital

    Auckland, 1023, New Zealand

  • Baystate Cardiac Surgery

    Springfield, Massachusetts, 01107, United States

  • C.H. Regional Reina Sofia - PPDS

    Córdoba, 14004, Spain

  • CHI Health Nebraska Heart

    Lincoln, Nebraska, 68526-9437, United States

  • CHU Angers

    Angers, 49933, France

  • CHU de Reims

    Reims, 51092, France

  • Duke University Medical Center

    Durham, North Carolina, 27705, United States

  • Fakultni nemocnice v Motole

    Prague, 150 06, Czechia

  • Fiona Stanley Hospital

    Murdoch, Western Australia, 6150, Australia

  • Gold Coast University Hospital

    Southport, Queensland, 4215, Australia

  • Herzzentrum Dresden GmbH Universitatsklinikum

    Dresden, 01307, Germany

  • Hopital de la Citadelle

    Liège, 4000, Belgium

  • Hospital Universitario Germans Trias i Pujol

    Badalona, Barcelona, 08916, Spain

  • Hospital Universitario de Bellvitge

    L'Hospitalet de Llobregat, Barcelona, 08907, Spain

  • Hospital Universitario de La Princesa

    Madrid, 28006, Spain

  • James A Haley Veteran Affairs Medical Center - NAVREF - PPDS

    Tampa, Florida, 33612-4745, United States

  • John Hopkins Hospital

    Lutherville, Maryland, 21093, United States

  • Mayo Clinic - PPDS

    Rochester, Minnesota, 55905-0001, United States

  • Radboud Universitair Medisch Centrum

    Nijmegen, 6525 GA, Netherlands

  • Richmond VA Medical Center NAVREF PPDS

    Richmond, Virginia, 99999, United States

  • Royal Infirmary of Edinburgh

    Edinburgh, EH16 4SA, United Kingdom

  • Saint John Regional Hospital

    Saint John, New Brunswick, E2L 4L2, Canada

  • Samsung Medical Center - PPDS

    Seoul, 06351, South Korea

  • Severance Hospital Yonsei University Health System - PPDS

    Seoul, 03722, South Korea

  • Southampton General Hospital

    Southampton, SO16 6YD, United Kingdom

  • Townsville Hospital

    Townsville, Queensland, 4810, Australia

  • UZ Leuven

    Leuven, 3000, Belgium

  • University of Stanford Medical Center

    Stanford, California, 94305-2200, United States

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390-7202, United States

  • Universitätsklinikum Essen

    Essen, 45147, Germany

  • Vseobecna fakultni nemocnice v Praze

    Prague, 12808, Czechia

  • Waikato Hospital

    Hamilton, 3248, New Zealand

  • ZOL Genk campus Sint Jan

    Genk, 3600, Belgium

Conditions

Explore the condition pages connected to this study.