Could a 12-Week TB pill combo replace 6 months of treatment?

NCT ID NCT05556746

First seen Feb 13, 2026 · Last updated May 24, 2026 · Updated 17 times

Summary

This study tests whether a 12-week combination of four drugs (bedaquiline, clofazimine, pyrazinamide, and delamanid) can treat drug-susceptible tuberculosis faster than the standard 6-month regimen. About 94 adults with active TB in the lungs will be randomly assigned to either the short course or standard therapy. The main goal is to see if the short course clears the bacteria from sputum more quickly and safely.

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Contacts and locations

Locations

  • GHESKIO

    Port-au-Prince, Haiti

  • University of Cape Town

    Cape Town, South Africa

Conditions

Explore the condition pages connected to this study.