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AI model predicts brain fog risk in kids after tumor surgery

NCT ID NCT07350382

Knowledge-focused Sponsor: West China Hospital Source: ClinicalTrials.gov ↗

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Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
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Cancelled
Cancelled before anyone took part.

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Approved
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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at medical records of 600 children who had brain tumor surgery to find out which kids might have long-term thinking or memory problems. Researchers used machine learning to create a tool that predicts this risk based on brain scans, tumor details, and treatment history. The goal is to help doctors identify high-risk children early so they can get extra support.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

600 people

The number who actually took part.

Started

Jan 2015

Finished

Jan 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study includes 600 children aged 0-18 years who underwent surgical resection of a primary posterior fossa tumor (e.g., medulloblastoma, ependymoma, or pilocytic astrocytoma). All participants had preoperative brain MRI with diffusion tensor imaging (DTI), received standard-of-care treatment, and completed comprehensive neuropsychological assessments at approximately 1 year post-surgery. The cohort represents a real-world pediatric neuro-oncology population treated at multiple tertiary care centers.

Ages

Up to 18 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 0-18 years at time of surgery * Histopathologically confirmed primary posterior fossa tumor (e.g., medulloblastoma, ependymoma, pilocytic astrocytoma) * Underwent surgical resection of the tumor at the hospital * Availability of preoperative brain MRI and diffusion tensor imaging (DTI) * Completed standardized neuropsychological assessment at approximately 1 year post-surgery Exclusion Criteria: * Pre-existing neurological or neurodevelopmental disorders (e.g., autism, intellectual disability, cerebral palsy) * History of prior cranial irradiation or chemotherapy before posterior fossa surgery * Incomplete clinical, imaging, or follow-up data required for model variables * Tumor recurrence or progression before 1-year cognitive assessment * Non-posterior fossa primary brain tumors (e.g., supratentorial gliomas)

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Conditions

The condition(s) this trial relates to.

Cerebellar Cognitive Affective Syndrome childhood neoplasm Cognitive Dysfunction infratentorial cancer infratentorial neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pediatric tumor of brain Posterior fossa tumors

Contacts and locations

Locations

  • West China Hospital of Sichuan University

    Chengdu, Sichuan, China

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