Personalized dosing could improve lupus kidney treatment for kids
NCT ID NCT05538208
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two ways of dosing the drug mycophenolate mofetil (MMF) for children with lupus nephritis, a kidney disease caused by lupus. One method uses a standard dose based on body size, while the other adjusts the dose based on drug levels in the blood. The goal is to see if personalized dosing leads to better kidney remission after 26 weeks. About 105 children aged 8 to under 21 are being enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mycophenolate mofetil (MMF)
What this could lead to
If successful, this could provide a more effective way to control lupus nephritis in children, potentially reducing kidney damage and improving long-term outcomes.
What could go wrong
This is a Phase 2 trial with only 105 participants, so results may not apply to all patients. The personalized dosing approach may not prove superior to standard dosing, and MMF can have side effects like infection risk.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Akron Children's Hospital
RECRUITINGAkron, Ohio, 44307, United States
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Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60614, United States
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Baylor College of Medicine Pediatric Immunology Allergy Rheumatology
RECRUITINGHouston, Texas, 77030, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital Colorado
RECRUITINGAurora, Colorado, 80045, United States
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Children's Hospital at Montefiore
RECRUITINGNew York, New York, 10467, United States
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Children's Wisconsin/Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45223, United States
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Emory Children's Center
RECRUITINGAtlanta, Georgia, 30322, United States
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Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601, United States
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Hospital for Special Surgery
RECRUITINGNew York, New York, 10021, United States
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Seattle Children's Hospital/University of Washington
RECRUITINGSeattle, Washington, 98105, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospitals Cleveland Medical Center
RECRUITINGCleveland, Ohio, 44106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94518, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Chicago Medicine- Comer Children's
RECRUITINGChicago, Illinois, 60637, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of North Carolina at Chapel Hill
RECRUITINGChapel Hill, North Carolina, 27599, United States
Contact Email: •••••@•••••
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University of Utah
RECRUITINGSalt Lake City, Utah, 84132, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Washington University in St. Louis School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••