Personalized dosing could improve lupus kidney treatment for kids

NCT ID NCT05538208

Recruiting now Disease control Sponsor: Children's Hospital Medical Center, Cincinnati Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two ways of dosing the drug mycophenolate mofetil (MMF) for children with lupus nephritis, a kidney disease caused by lupus. One method uses a standard dose based on body size, while the other adjusts the dose based on drug levels in the blood. The goal is to see if personalized dosing leads to better kidney remission after 26 weeks. About 105 children aged 8 to under 21 are being enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mycophenolate mofetil (MMF)
What this could lead to: If successful, this could provide a more effective way to control lupus nephritis in children, potentially reducing kidney damage and improving long-term outcomes.
What could go wrong: This is a Phase 2 trial with only 105 participants, so results may not apply to all patients. The personalized dosing approach may not prove superior to standard dosing, and MMF can have side effects like infection risk.

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Conditions

The condition(s) this trial relates to.

lupus nephritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUPUS NEPHRITIS

Contacts and locations

Locations

Akron Children's Hospital
RECRUITING

Akron, Ohio, 44307, United States
Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60614, United States
Baylor College of Medicine Pediatric Immunology Allergy Rheumatology
RECRUITING

Houston, Texas, 77030, United States
Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital at Montefiore
RECRUITING

New York, New York, 10467, United States
Children's Wisconsin/Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45223, United States
Emory Children's Center
RECRUITING

Atlanta, Georgia, 30322, United States
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Hospital for Special Surgery
RECRUITING

New York, New York, 10021, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
Seattle Children's Hospital/University of Washington
RECRUITING

Seattle, Washington, 98105, United States
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University of California, San Francisco
RECRUITING

San Francisco, California, 94518, United States
University of Chicago Medicine- Comer Children's
RECRUITING

Chicago, Illinois, 60637, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84132, United States
Washington University in St. Louis School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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