Which hormone best prevents endometrioma return after surgery?

NCT ID NCT07519213

Completed Disease control Sponsor: Guangdong Women and Children Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This study looked at over 1,100 women who had surgery for ovarian endometriomas (cysts caused by endometriosis) and then took one of four hormonal treatments to prevent recurrence. The goal was to see which treatment—birth control pills, GnRH agonists, dienogest, or dydrogesterone—was most effective at stopping new cysts from forming within two years. Results could help doctors choose the best post-surgery hormone therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hormonal treatments (combined oral contraceptives, GnRH agonists, dienogest, or dydrogesterone)
What this could lead to: If this study shows one hormonal regimen works better, it could help doctors choose the best option to prevent endometriomas from coming back after surgery.
What could go wrong: This is a retrospective study, not a controlled trial, so results may be influenced by unmeasured factors. The findings need confirmation in prospective studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endometriosis ovarian endometriosis Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOMETRIOSIS OVARIAN ENDOMETRIOMA

Contacts and locations

Locations

Guangdong Women and Children Hospital

Guangzhou, Guangdong, 511400, China

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