Eye implant could replace monthly shots for diabetes-related vision loss

NCT ID NCT04108156

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a small, refillable implant placed in the eye that delivers medication every 24 weeks, compared to standard monthly eye injections. It includes about 634 adults with diabetic macular edema, a condition that causes vision loss. The goal is to see if the implant works as well as monthly shots while reducing the number of treatments needed.

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Conditions

The condition(s) this trial relates to.

diabetic macular edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC MACULAR EDEMA

Contacts and locations

Show contact details

Locations

Arizona Retina and Vitreous Consultants

Phoenix, Arizona, 85016, United States
Asheville Eye Associates Western Carolina Retinal Associates;Clinical Research

Asheville, North Carolina, 28803, United States
Associated Retina Consultants

Phoenix, Arizona, 85020, United States
Associated Retinal Consultants - Royal Oak

Royal Oak, Michigan, 48073, United States
Austin Clinical Research, LLC

Austin, Texas, 78750, United States
Austin Research Center for Retina

Austin, Texas, 78705, United States
Austin Retina Associates;Opthalmology

Austin, Texas, 78705, United States
Barnet Dulaney Perkins Eye Center

Mesa, Arizona, 85206, United States
California Eye Specialists Medical Group

Pasadena, California, 91107, United States
California Retina Consultants

Bakersfield, California, 93309, United States
California Retina Consultants;Research Department

Santa Barbara, California, 93103, United States
Carolina Eyecare Physicians

Mt. Pleasant, South Carolina, 29464, United States
Charles Retina Institution;Retina surgery

Germantown, Tennessee, 38138, United States
Charleston Neuroscience

Ladson, South Carolina, 29456, United States
Charlotte Eye Ear Nose and Throat Associates- SouthPark;Retina

Charlotte, North Carolina, 28210, United States
Cincinnati Eye Institute;Retina

Cincinnati, Ohio, 45242, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Colorado Clinical Research

Lakewood, Colorado, 80228, United States
Cumberland Valley Retina Consultants;Clinical Research

Hagerstown, Maryland, 21740, United States
Doheny Eye Institute

Pasadena, California, 91105, United States
Duke Eye Center

Durham, North Carolina, 27705, United States
East Bay Retina Consultants

Oakland, California, 94609, United States
Envision Ocular, LLC

Bloomfield, New Jersey, 07003, United States
Eye Center of Northern Colorado

Fort Collins, Colorado, 80528, United States
Fort Lauderdale Eye Institute

Plantation, Florida, 33324, United States
Georgia Retina

Marietta, Georgia, 30060, United States
Graystone Eye;Clinical Research

Hickory, North Carolina, 28602, United States
Illinois Retina Associates

Joliet, Illinois, 60435, United States
Johns Hopkins Hospital;Johns Hopkins Med;Wilmer Eye Inst

Baltimore, Maryland, 21287, United States
Jules Stein Eye Institute/ UCLA

Los Angeles, California, 90095, United States
Long Island Vitreoretinal Consultants;Opthalmology

Great Neck, New York, 11021, United States
Maine Eye Center

Portland, Maine, 04605, United States
Medical Center Ophthalmology Associates

San Antonio, Texas, 78240, United States
Mid Atlantic Retina

Philadelphia, Pennsylvania, 19107, United States
Midwest Retina;Retina/Vitreous

Dublin, Ohio, 43016, United States
National Ophthalmic Research Institute

Fort Myers, Florida, 33912, United States
New York University (NYU)

New York, New York, 10017, United States
Northern California Retina-Vitreous Associates

Mountain View, California, 94040, United States
Northwestern Memorial Hospital

Chicago, Illinois, 60611, United States
Ohio State Havener Eye Institute;Ophthalmology Research

Columbus, Ohio, 43212, United States
Ophthalmic Consultants of Boston

Boston, Massachusetts, 02114, United States
Ophthalmic Consultants of Long Island

Oceanside, New York, 11572, United States
Orange County Retina Medical Group

Santa Ana, California, 92705, United States
Pacific Northwest Retina

Silverdale, Washington, 98383, United States
Palmetto Retina Center

West Columbia, South Carolina, 29169, United States
Pepose Vision Institute

Chesterfield, Missouri, 63017, United States
Piedmont Eye Center

Lynchburg, Virginia, 24502, United States
Retina & Vitreous Associates of Kentucky

Lexington, Kentucky, 40509, United States
Retina & Vitreous of Texas

Bellaire, Texas, 77401, United States
Retina Associates

Lenexa, Kansas, 66215, United States
Retina Associates of Florida;Retina Associates of Florida

Tampa, Florida, 33609, United States
Retina Associates of New Jersey

Teaneck, New Jersey, 07666, United States
Retina Associates of Utah, PLLC;Clinical Research

Salt Lake City, Utah, 84107, United States
Retina Consultants Medical Group

Sacramento, California, 95841, United States
Retina Consultants of Orange County;Clinical Research

Fullerton, California, 92835, United States
Retina Consultants of Texas

Houston, Texas, 77401, United States
Retina Group of Florida

Fort Lauderdale, Florida, 33308, United States
Retina Group of New England

Waterford, Connecticut, 06385, United States
Retina Institute

St Louis, Missouri, 63128, United States
Retina Institute of Virginia

Richmond, Virginia, 23235, United States
Retina Northwest;Research Department

Portland, Oregon, 97221, United States
Retina Research Institute of Texas

Abilene, Texas, 79606, United States
Retina Specialist

Towson, Maryland, 21204, United States
Retina Specialists Of Michigan

Grand Rapids, Michigan, 49546, United States
Retina Specialty Institute

Pensacola, Florida, 32503, United States
Retina Vitreous Associates of Florida

St. Petersburg, Florida, 33711, United States
Retina Vitreous Center - Glen Eagles

Edmond, Oklahoma, 73013, United States
Retina Vitreous Surgeons of Central New York

Liverpool, New York, 13088, United States
Retina-Vitreous Associates Medical Group

Beverly Hills, California, 90211, United States
Retinal Consultants of Arizona;Opthalmology

Phoenix, Arizona, 85014, United States
Rocky Mountain Retina Consultants

Murray, Utah, 84107, United States
Sierra Eye Associates

Reno, Nevada, 89502, United States
Southeast Retina Center

Augusta, Georgia, 30909, United States
Southern Vitreoretinal Associates;Research

Tallahassee, Florida, 32308, United States
Spokane Eye Clinical Research;Spokane Eye Surgery Center

Spokane, Washington, 99204, United States
Tennessee Retina

Nashville, Tennessee, 37203, United States
Texas Retina Associates

Arlington, Texas, 76012, United States
Texas Retina Associates

Fort Worth, Texas, 76104, United States
Texas Retina Associates;Research

Dallas, Texas, 75231, United States
The Retina Group of Washington;Retinal Disease

Chevy Chase, Maryland, 20815, United States
The Retina Partners

Encino, California, 91436, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
University Retina

Lemont, Illinois, 60439, United States
Vitreo Retinal Associates

Worcester, Massachusetts, 01605, United States
VitreoRetinal Surgery PLLC;DBA Retina Consultants of Minnesota

Minneapolis, Minnesota, 55435, United States
Wagner Kapoor Institute;Opthalmology

Norfolk, Virginia, 23502, United States
Wolfe Eye Clinic

West Des Moines, Iowa, 50266, United States
Zuckerberg San Francisco General Hospital and Trauma Center

San Francisco, California, 94110, United States