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New combo shows promise for Tough-to-Treat blood cancer

NCT ID NCT01946477

Completed Disease control Sponsor: Celgene Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two drug combinations in 186 adults with multiple myeloma that came back or didn't respond after earlier treatment. One group got pomalidomide plus low-dose dexamethasone, and another got those two plus daratumumab. The goal was to see if the tumors shrank enough to qualify as a partial or complete response. The approach aims to control the disease, not cure it, and participants may need ongoing therapy.

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Conditions

The condition(s) this trial relates to.

neoplasm plasma cell myeloma plasmacytoma refractory plasma cell neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE MYELOMA

Contacts and locations

Locations

  • Local Institution - 101

    Hackensack, New Jersey, 07601, United States

  • Local Institution - 102

    Kansas City, Missouri, 64111, United States

  • Local Institution - 103

    Westminster, Maryland, 21157, United States

  • Local Institution - 104

    Pleasant Hill, California, 94523, United States

  • Local Institution - 106

    Spokane, Washington, 99218, United States

  • Local Institution - 107

    Hershey, Pennsylvania, 17033-0850, United States

  • Local Institution - 108

    Whittier, California, 90603, United States

  • Local Institution - 109

    Los Angeles, California, 90095-1670, United States

  • Local Institution - 110

    St Louis, Missouri, 63110, United States

  • Local Institution - 112

    Toronto, Ontario, M5G 2M9, Canada

  • Local Institution - 113

    Calgary, Alberta, T2N 2T9, Canada

  • Local Institution - 114

    Vancouver, British Columbia, V5Z 4E6, Canada

  • Local Institution - 115

    Cleveland, Ohio, 44195, United States

  • Local Institution - 117

    Montreal, Quebec, H3A 1A1, Canada

  • Local Institution - 118

    East Orange, New Jersey, 07018, United States

  • Local Institution - 119

    San Juan, 00927, Puerto Rico

  • Local Institution - 120

    Stamford, Connecticut, 06902, United States

  • Local Institution - 121

    Cleveland, Ohio, 44111, United States

  • Local Institution - 122

    Mayfield Heights, Ohio, 44124, United States

  • Local Institution - 123

    Cleveland, Ohio, 44106, United States

  • Local Institution - 124

    Louisville, Kentucky, 40207, United States

  • Local Institution - 126

    Tucson, Arizona, 85724, United States

  • Local Institution - 127

    Orlando, Florida, 32804, United States

  • Local Institution - 128

    Lubbock, Texas, 79410, United States

  • Local Institution - 129

    Glens Falls, New York, 12801, United States

  • Local Institution - 130

    Durham, North Carolina, 27705, United States

  • Local Institution - 131

    Nashville, Tennessee, 37203, United States

  • Local Institution - 133

    Pembroke Pines, Florida, 33028, United States

  • Local Institution - 134

    Fairway, Kansas, 66205, United States

  • Local Institution - 135

    Chattanooga, Tennessee, 37404, United States

  • Local Institution - 136

    St. Petersburg, Florida, 33705, United States

  • Local Institution - 137

    Greenbrae, California, 94904-2007, United States

  • Local Institution - 138

    Denver, Colorado, 80218, United States

  • Local Institution - 139

    Moncton, New Brunswick, E1C 8X3, Canada

  • Local Institution - 140

    St. John's, Newfoundland and Labrador, A1B3V6, Canada

  • Local Institution - 142

    Topeka, Kansas, 66606, United States

  • Local Institution - 143

    Plano, Texas, 75093, United States

  • Local Institution - 144

    Surrey, British Columbia, V3V 1Z2, Canada

  • Local Institution - 145

    Jacksonville, Florida, 32256, United States

  • Local Institution - 146

    Gross Pointe, Michigan, 48236, United States

  • Local Institution - 148

    Toronto, Ontario, M5G 2M9, Canada

  • Local Institution - 149

    The Bronx, New York, 10467, United States

  • Local Institution - 202

    Nagoya, 467-8602, Japan

  • Local Institution - 203

    Okayama, 701-1192, Japan

  • Local Institution - 204

    Kyoto, 602-8566, Japan

  • Local Institution - 205

    Fukuoka, Fukuoka, 810-8563, Japan

  • Local Institution - 206

    Shibukawa-shi, Gunma-ken, 377-0280, Japan

  • Local Institution - 207

    Toyohashi, 441-8570, Japan

  • Local Institution - 208

    Kamogawa, 296-8602, Japan

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