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Could targeted exercises turn down fatigue in myasthenia gravis?

NCT ID NCT06158815

Symptom relief Sponsor: Hacettepe University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

This trial tests whether proprioceptive neuromuscular facilitation exercises, a type of movement therapy that uses resistance and sensory cues, can reduce fatigue and improve muscle strength and daily function in people with myasthenia gravis. About 23 adults with stable generalized myasthenia gravis will be split into two groups: one does the exercises three times a week for six weeks, while the other waits. Researchers will compare fatigue, strength, and walking ability between the groups to see if the exercises help.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
proprioceptive neuromuscular facilitation exercises
What this could lead to
If these exercises work, they could offer a drug-free way to ease fatigue and improve muscle strength and daily function for people with myasthenia gravis.
What could go wrong
This is a small, early-stage trial with only 23 participants, so results may not apply broadly. Exercise might also be hard for some patients to tolerate, and the study does not test long-term effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

23 people

The number who actually took part.

Started

Nov 2023

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Volunteering to participate in the study * Being between the ages of 18-65 * It must be confirmed by the Neurologist that the patient has been diagnosed with adult onset and Achr+ generalized Myasthenia Gravis and has been in a stable condition for the last 6 months. * Being in class II or III according to the American Myasthenia Gravis Foundation Clinical Classification Exclusion Criteria: * Having a cognitive problem or having a Mini Mental Test score below 24 * Change in the type and dose of medical treatment within the last 6 months * Having another cardiorespiratory, metabolic, systemic, rheumatological, orthopaedic and neurological disease (unstable and at a level that prevents participation in the exercise programme) in addition to Myasthenia Gravis * Having a body mass index below 17 kg/m2 and above 30 kg/m2 * Having participated in any physiotherapy program any intervention study for the last 6 months * Having undergone pregnancy, birth or surgical operation in the last 6 months.

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Conditions

The condition(s) this trial relates to.

myasthenia gravis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Myasthenia gravis

Contacts and locations

Locations

  • Hacettepe University Faculty of Physical Therapy and Rehabilitation

    Ankara, Altındag, 06230, Turkey (Türkiye)

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