Can a Once-Daily pill ease chronic constipation in kids?

NCT ID NCT07723924

Ongoing Symptom relief Sponsor: Bausch Health Americas, Inc. Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial tests whether plecanatide, a drug taken by mouth once a day, can safely improve bowel movements in children and adolescents aged 6 to 17 with functional constipation. Participants receive either low-dose plecanatide, high-dose plecanatide, or a placebo for 8 weeks. The study tracks changes in weekly spontaneous bowel movements and monitors for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: plecanatide
What this could lead to: If it works, this could offer a new, once-daily treatment option for children with chronic constipation.
What could go wrong: This is a mid-stage trial with only 180 participants, so results may not apply to all children. Side effects are possible, and the drug may not work better than placebo.

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Conditions

The condition(s) this trial relates to.

constipation disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FUNCTIONAL CONSTIPATION (FC)

Contacts and locations

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Locations

AppleMedical Research Group, Inc

Miami, Florida, 33126, United States

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