New hope for aggressive lung cancer: phase 3 trial launches

NCT ID NCT06646276

Recruiting now Disease control Sponsor: Bristol-Myers Squibb Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Jun 19, 2026 · Updated 28 times

Summary

This phase 3 trial is testing a new combination of drugs (BMS-986489) plus chemotherapy against a standard treatment (atezolizumab plus chemotherapy) for people with extensive-stage small cell lung cancer, a fast-growing cancer. The study aims to see if the new combo helps people live longer. It is recruiting 530 participants worldwide.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Locations

Duke Cancer Institute
RECRUITING

Durham, North Carolina, 27710, United States

Contact Phone: •••-•••-••••
Florida Cancer Specialists - North
RECRUITING

St. Petersburg, Florida, 33705, United States

Contact Phone: •••-•••-••••
Florida Cancer Specialists - South
RECRUITING

Fort Myers, Florida, 33901, United States

Contact Phone: •••-•••-••••
Hospital Kuala Lumpur
RECRUITING

Kuala Lumpur, Kuala Lumpur, 50586, Malaysia

Contact Phone: •••-•••-••••
Illinois Cancer Care
RECRUITING

Peoria, Illinois, 61615, United States

Contact Phone: •••-•••-••••
Institutul Regional de Oncologie
RECRUITING

Iași, 700483, Romania

Contact Phone: •••-•••-••••
Local Institution - 0037
WITHDRAWN

Minneapolis, Minnesota, 55407, United States
Local Institution - 0038
ACTIVE_NOT_RECRUITING

Villejuif, Val-de-Marne, 94800, France
Local Institution - 0040
ACTIVE_NOT_RECRUITING

La Tronche, Isère, 38700, France
Local Institution - 0043
ACTIVE_NOT_RECRUITING

Marseille, 13915, France
Local Institution - 0044
COMPLETED

Gleizé, Rhône, 69400, France
Local Institution - 0047
COMPLETED

Créteil, Val-de-Marne, 94010, France
Local Institution - 0048
COMPLETED

Montpellier, Hérault, 34090, France
Local Institution - 0050
ACTIVE_NOT_RECRUITING

Paris, 75248, France
Local Institution - 0051
ACTIVE_NOT_RECRUITING

Pierre-Bénite, Rhône, 69310, France
Local Institution - 0052
COMPLETED

Lille, Nord, 59037, France
Local Institution - 0058
ACTIVE_NOT_RECRUITING

Thessaloniki, Thessaloníki, 570 01, Greece
Local Institution - 0059
COMPLETED

Larissa, Thessalía, 41110, Greece
Local Institution - 0062
COMPLETED

Thessaloniki, Kentrikí Makedonía, 540 07, Greece
Local Institution - 0063
ACTIVE_NOT_RECRUITING

Athens, Attikí, 115 26, Greece
Local Institution - 0064
ACTIVE_NOT_RECRUITING

Athens, Attikí, 115 27, Greece
Local Institution - 0067
ACTIVE_NOT_RECRUITING

Milan, 20141, Italy
Local Institution - 0068
ACTIVE_NOT_RECRUITING

Milan, Lombardy, 20133, Italy
Local Institution - 0069
ACTIVE_NOT_RECRUITING

Rome, Roma, 00144, Italy
Local Institution - 0070
ACTIVE_NOT_RECRUITING

Peschiera del Garda, Verona, 37019, Italy
Local Institution - 0072
ACTIVE_NOT_RECRUITING

Naples, Campania, 80131, Italy
Local Institution - 0074
ACTIVE_NOT_RECRUITING

Bologna, 40138, Italy
Local Institution - 0077
ACTIVE_NOT_RECRUITING

ABB, Buenos Aires F.D., C1199ABB, Argentina
Local Institution - 0079
COMPLETED

Ciudad Autónoma de Buenos Aires, Buenos Aires, C1426ANZ, Argentina
Local Institution - 0080
ACTIVE_NOT_RECRUITING

CABA, Buenos Aires F.D., C1430EGF, Argentina
Local Institution - 0082
ACTIVE_NOT_RECRUITING

Viña del Mar, Valparaiso, 2520598, Chile
Local Institution - 0083
ACTIVE_NOT_RECRUITING

Santiago, Santiago Metropolitan, 8330032, Chile
Local Institution - 0084
ACTIVE_NOT_RECRUITING

Santiago, Santiago Metropolitan, 8420383, Chile
Local Institution - 0085
ACTIVE_NOT_RECRUITING

Santiago, Santiago Metropolitan, 7500921, Chile
Local Institution - 0086
ACTIVE_NOT_RECRUITING

Santiago, Santiago Metropolitan, 0, Chile
Local Institution - 0091
ACTIVE_NOT_RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium
Local Institution - 0092
ACTIVE_NOT_RECRUITING

Liège, 4000, Belgium
Local Institution - 0094
ACTIVE_NOT_RECRUITING

Río Cuarto, Córdoba Province, X5800AEV, Argentina
Local Institution - 0097
COMPLETED

Amsterdam, North Holland, 1081 HV, Netherlands
Local Institution - 0098
ACTIVE_NOT_RECRUITING

Groningen, 9713 GZ, Netherlands
Local Institution - 0099
ACTIVE_NOT_RECRUITING

Arnhem, 6815 AD, Netherlands
Local Institution - 0100
WITHDRAWN

Buenos Aires, Buenos Aires F.D., C1417DTB, Argentina
Local Institution - 0101
ACTIVE_NOT_RECRUITING

Manchester, M20 4BX, United Kingdom
Local Institution - 0105
ACTIVE_NOT_RECRUITING

Brisbane, Queensland, 4120, Australia
Local Institution - 0106
ACTIVE_NOT_RECRUITING

Penrith, New South Wales, 2750, Australia
Local Institution - 0110
ACTIVE_NOT_RECRUITING

Perugia, Umbria, 06132, Italy
Local Institution - 0111
ACTIVE_NOT_RECRUITING

São Paulo, São Paulo, 01509-010, Brazil
Local Institution - 0113
ACTIVE_NOT_RECRUITING

Prague, Praha 4, 14059, Czechia
Local Institution - 0114
ACTIVE_NOT_RECRUITING

Brno, Brno-město, 656 53, Czechia
Local Institution - 0116
ACTIVE_NOT_RECRUITING

Olomouc, 779 00, Czechia
Local Institution - 0117
ACTIVE_NOT_RECRUITING

Ostrava, Ostrava Město, 703 00, Czechia
Local Institution - 0133
ACTIVE_NOT_RECRUITING

Bucharest, Bucharest, 013812, Romania
Local Institution - 0135
ACTIVE_NOT_RECRUITING

Bucharest, Bucharest, 022328, Romania
Local Institution - 0137
ACTIVE_NOT_RECRUITING

Florești, Cluj, 407280, Romania
Local Institution - 0140
ACTIVE_NOT_RECRUITING

Craiova, Dolj, 200542, Romania
Local Institution - 0141
ACTIVE_NOT_RECRUITING

Cluj-Napoca, 400015, Romania
Local Institution - 0145
ACTIVE_NOT_RECRUITING

Puebla City, 72424, Mexico
Local Institution - 0146
ACTIVE_NOT_RECRUITING

Guadalajara, Jalisco, 44630, Mexico
Local Institution - 0153
ACTIVE_NOT_RECRUITING

Istanbul, 34732, Turkey (Türkiye)
Local Institution - 0154
ACTIVE_NOT_RECRUITING

Adana, 01370, Turkey (Türkiye)
Local Institution - 0157
ACTIVE_NOT_RECRUITING

Ankara, 06010, Turkey (Türkiye)
Local Institution - 0158
ACTIVE_NOT_RECRUITING

Çiğli, İzmir, 35620, Turkey (Türkiye)
Local Institution - 0159
COMPLETED

Aberdeen, AB9 2ZB, United Kingdom
Local Institution - 0163
ACTIVE_NOT_RECRUITING

Itajaí, Santa Catarina, 88301-220, Brazil
Local Institution - 0165
ACTIVE_NOT_RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Local Institution - 0166
ACTIVE_NOT_RECRUITING

Fortaleza, Ceará, 60135-237, Brazil
Local Institution - 0169
ACTIVE_NOT_RECRUITING

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Local Institution - 0170
COMPLETED

Santa Cruz do Sul, Rio Grande do Sul, 96830-180, Brazil
Local Institution - 0175
ACTIVE_NOT_RECRUITING

Murdoch, Western Australia, 6150, Australia
Local Institution - 0177
ACTIVE_NOT_RECRUITING

Ankara, 06280, Turkey (Türkiye)
Local Institution - 0178
ACTIVE_NOT_RECRUITING

Barretos, São Paulo, 14784400, Brazil
Local Institution - 0183
COMPLETED

Central Middlesbrough, Middlesbrough, TS4 3BW, United Kingdom
Local Institution - 0186
ACTIVE_NOT_RECRUITING

Shanghai, Shanghai Municipality, 200120, China
Local Institution - 0187
ACTIVE_NOT_RECRUITING

Sint-Niklaas, Oost-Vlaanderen, B-9100, Belgium
Local Institution - 0189
ACTIVE_NOT_RECRUITING

Lodz, Łódź Voivodeship, 93-338, Poland
Local Institution - 0190
ACTIVE_NOT_RECRUITING

Ballarat Central, Victoria, 3350, Australia
Local Institution - 0192
ACTIVE_NOT_RECRUITING

Prabuty, Pomeranian Voivodeship, 82-550, Poland
Local Institution - 0193
ACTIVE_NOT_RECRUITING

Konin, Greater Poland Voivodeship, 62-500, Poland
Local Institution - 0195
ACTIVE_NOT_RECRUITING

Bydgoszcz, 85796, Poland
Local Institution - 0198
ACTIVE_NOT_RECRUITING

Brussels, Bruxelles-Capitale, Région de, 1200, Belgium
Local Institution - 0200
ACTIVE_NOT_RECRUITING

Jinan, Shandong, 250117, China
Local Institution - 0202
ACTIVE_NOT_RECRUITING

Campbelltown, New South Wales, 2560, Australia
Local Institution - 0203
ACTIVE_NOT_RECRUITING

Chongqing, Chongqing Municipality, 400030, China
Local Institution - 0204
COMPLETED

Beijing, Beijing Municipality, 100142, China
Local Institution - 0206
ACTIVE_NOT_RECRUITING

Shanghai, Shanghai Municipality, 200030, China
Local Institution - 0208
ACTIVE_NOT_RECRUITING

Wuhan, Hubei, 430100, China
Local Institution - 0209
ACTIVE_NOT_RECRUITING

Wuhan, Hubei, 430079, China
Local Institution - 0210
ACTIVE_NOT_RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Local Institution - 0212
COMPLETED

Xiamen, Fujian, 361003, China
Local Institution - 0213
ACTIVE_NOT_RECRUITING

Tianjin, Tianjin Municipality, 300060, China
Local Institution - 0215
ACTIVE_NOT_RECRUITING

Quimper, 29000, France
Local Institution - 0216
ACTIVE_NOT_RECRUITING

Changsha, Hunan, 410013, China
Local Institution - 0226
ACTIVE_NOT_RECRUITING

Metropolitan Borough of Wirral, CH63 4JY, United Kingdom
Local Institution - 0227
ACTIVE_NOT_RECRUITING

Harbin, Heilongjiang, 150081, China
Local Institution - 0229
ACTIVE_NOT_RECRUITING

Linhai, Zhejiang, 317000, China
Local Institution - 0233
ACTIVE_NOT_RECRUITING

Nanchang, Jiangxi, 330006, China
Local Institution - 0234
ACTIVE_NOT_RECRUITING

Shantou, Guangdong, 515000, China
Local Institution - 0235
NOT_YET_RECRUITING

Shenyang, Liaoning, 110042, China

Contact
Local Institution - 0236
ACTIVE_NOT_RECRUITING

Hangzhou, Zhejiang, 310016, China
Local Institution - 0237
ACTIVE_NOT_RECRUITING

Hangzhou, Zhejiang, 310022, China
Local Institution - 0241
ACTIVE_NOT_RECRUITING

Poznan, Greater Poland Voivodeship, 60-192, Poland
Local Institution - 0244
ACTIVE_NOT_RECRUITING

Changchun, Jilin, 132000, China
Local Institution - 0247
ACTIVE_NOT_RECRUITING

Zurich, 8091, Switzerland
Local Institution - 0248
ACTIVE_NOT_RECRUITING

Chur, 7000, Switzerland
Local Institution - 0249
ACTIVE_NOT_RECRUITING

Winterthur, 8401, Switzerland
Local Institution - 0251
ACTIVE_NOT_RECRUITING

Wels, Upper Austria, 4600, Austria
Local Institution - 0252
ACTIVE_NOT_RECRUITING

Linz, 4021, Austria
Local Institution - 0253
ACTIVE_NOT_RECRUITING

Graz, Styria, 8036, Austria
Local Institution - 0255
ACTIVE_NOT_RECRUITING

Rankweil, 6830, Austria
Local Institution - 0256
ACTIVE_NOT_RECRUITING

Frankfurt am Main, Hesse, 60488, Germany
Local Institution - 0257
ACTIVE_NOT_RECRUITING

Bad Berka, Thuringia, 99437, Germany
Local Institution - 0258
ACTIVE_NOT_RECRUITING

Gauting, 82131, Germany
Local Institution - 0259
ACTIVE_NOT_RECRUITING

Großhansdorf, 22927, Germany
Local Institution - 0261
ACTIVE_NOT_RECRUITING

Cologne, North Rhine-Westphalia, 51109, Germany
Local Institution - 0262
ACTIVE_NOT_RECRUITING

Oldenburg, Lower Saxony, 26121, Germany
Local Institution - 0264
ACTIVE_NOT_RECRUITING

Stuttgart, 70736, Germany
Local Institution - 0265
ACTIVE_NOT_RECRUITING

Halle, Saxony-Anhalt, 06120, Germany
Local Institution - 0271
ACTIVE_NOT_RECRUITING

Madurai, Tamil Nadu, 625107, India
Local Institution - 0273
ACTIVE_NOT_RECRUITING

Kolkata, West Bengal, 700094, India
Local Institution - 0274
ACTIVE_NOT_RECRUITING

Bengaluru, Karnataka, 560017, India
Local Institution - 0277
ACTIVE_NOT_RECRUITING

Varanasi, Uttar Pradesh, 221005, India
Local Institution - 0278
WITHDRAWN

New Delhi, National Capital Territory of Delhi, 110029, India
Local Institution - 0283
COMPLETED

Hot Springs, Arkansas, 71913, United States
Local Institution - 0285
ACTIVE_NOT_RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 03722, South Korea
Local Institution - 0286
ACTIVE_NOT_RECRUITING

Seongnam, Kyǒnggi-do, 13620, South Korea
Local Institution - 0287
ACTIVE_NOT_RECRUITING

Rimouski, Quebec, G5L 5T1, Canada
Local Institution - 0288
ACTIVE_NOT_RECRUITING

Québec, Quebec, G1V 4G5, Canada
Local Institution - 0289
ACTIVE_NOT_RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada
Local Institution - 0290
ACTIVE_NOT_RECRUITING

Chicoutimi, Quebec, G7H 5H6, Canada
Local Institution - 0291
ACTIVE_NOT_RECRUITING

Sendai, Miyagi, 9810914, Japan
Local Institution - 0292
ACTIVE_NOT_RECRUITING

Kurume, Fukuoka, 830-0011, Japan
Local Institution - 0293
ACTIVE_NOT_RECRUITING

Seoul, Seoul-teukbyeolsi [Seoul], 05505, South Korea
Local Institution - 0294
COMPLETED

Barcelona, Catalunya [Cataluña], 08036, Spain
Local Institution - 0295
ACTIVE_NOT_RECRUITING

Seville, 41013, Spain
Local Institution - 0296
ACTIVE_NOT_RECRUITING

Madrid, Madrid, Comunidad de, 28041, Spain
Local Institution - 0297
ACTIVE_NOT_RECRUITING

Majadahonda, Madrid, Comunidad de, 28222, Spain
Local Institution - 0298
ACTIVE_NOT_RECRUITING

Madrid, Madrid, Comunidad de, 28034, Spain
Local Institution - 0299
ACTIVE_NOT_RECRUITING

Seville, 41009, Spain
Local Institution - 0300
ACTIVE_NOT_RECRUITING

Santiago de Compostela, A Coruña [La Coruña], 15706, Spain
Local Institution - 0301
ACTIVE_NOT_RECRUITING

Jaén, Jaén, 23007, Spain
Local Institution - 0302
ACTIVE_NOT_RECRUITING

Barcelona, Catalunya [Cataluña], 08041, Spain
Local Institution - 0303
ACTIVE_NOT_RECRUITING

Valencia, Valenciana, Comunitat, 46014, Spain
Local Institution - 0304
ACTIVE_NOT_RECRUITING

Suwon, Kyǒnggi-do, 16499, South Korea
Local Institution - 0305
ACTIVE_NOT_RECRUITING

Cheongju-si, Chungcheongbuk-do [Chungbuk], 28644, South Korea
Local Institution - 0308
ACTIVE_NOT_RECRUITING

Fuzhou, Fujian, 350014, China
Local Institution - 0309
ACTIVE_NOT_RECRUITING

Daegu, Taegu-Kwangyǒkshi, 42601, South Korea
Local Institution - 0311
ACTIVE_NOT_RECRUITING

Kuching, Sarawak, 93586, Malaysia
Local Institution - 0312
COMPLETED

Kuala Lumpur, Kuala Lumpur, 50603, Malaysia
Local Institution - 0313
ACTIVE_NOT_RECRUITING

Sapporo, Hokkaido, 0608648, Japan
Local Institution - 0314
ACTIVE_NOT_RECRUITING

Ōsaka-sayama, Osaka, 589-8511, Japan
Local Institution - 0315
ACTIVE_NOT_RECRUITING

Koto, Tokyo, 135-8550, Japan
Local Institution - 0316
COMPLETED

Yokohama, Kanagawa, 236-0051, Japan
Local Institution - 0317
ACTIVE_NOT_RECRUITING

Hirakata, Osaka, 573-1191, Japan
Local Institution - 0318
ACTIVE_NOT_RECRUITING

Ina-machi, Saitama, 362-0806, Japan
Local Institution - 0319
ACTIVE_NOT_RECRUITING

Matsuyama, Ehime, 791-0280, Japan
Local Institution - 0320
ACTIVE_NOT_RECRUITING

Hidaka, Saitama, 350-1298, Japan
Local Institution - 0321
ACTIVE_NOT_RECRUITING

Kanazawa, Ishikawa-ken, 920-8641, Japan
Local Institution - 0322
ACTIVE_NOT_RECRUITING

Hamamatsu, Shizuoka, 431-3192, Japan
Local Institution - 0323
ACTIVE_NOT_RECRUITING

Kobe, Hyōgo, 650-0047, Japan
Local Institution - 0324
COMPLETED

Kashihara, Nara, 634-8522, Japan
Local Institution - 0325
COMPLETED

Takatsuki, Osaka, 569-8686, Japan
Local Institution - 0326
ACTIVE_NOT_RECRUITING

Bunkyo-ku, Tokyo, 1138603, Japan
Local Institution - 0327
ACTIVE_NOT_RECRUITING

Fukushima, 960-1295, Japan
Local Institution - 0328
ACTIVE_NOT_RECRUITING

Kurashiki, Okayama-ken, 710-8602, Japan
Local Institution - 0330
ACTIVE_NOT_RECRUITING

Chengdu, Sichuan, 610041, China
Local Institution - 0335
COMPLETED

Xi'an, Shaanxi, 710126, China
Local Institution - 0336
ACTIVE_NOT_RECRUITING

Beijing, Beijing Municipality, 101149, China
Mid Florida Hematology and Oncology Center
RECRUITING

Orange City, Florida, 32763, United States

Contact Phone: •••-•••-••••
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital
RECRUITING

Marietta, Georgia, 30060, United States

Contact Phone: •••-•••-••••
Oncology & Hematology Associates of Southwest Virginia, Inc.
RECRUITING

Roanoke, Virginia, 24014, United States

Contact Phone: •••-•••-••••
Oncology Hematology Care
RECRUITING

Cincinnati, Ohio, 45242, United States

Contact Phone: •••-•••-••••
S.C. Centrul de Oncologie Euroclinic S.R.L.
RECRUITING

Iași, 700106, Romania

Contact Phone: •••-•••-••••
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States

Contact Phone: •••-•••-••••
Sanford Cancer Center
RECRUITING

Sioux Falls, South Dakota, 57104, United States

Contact Phone: •••-•••-••••
Sanford Fargo Medical Center
RECRUITING

Fargo, North Dakota, 58102, United States

Contact Phone: •••-•••-••••
Sanford Medical Center
RECRUITING

Bismarck, North Dakota, 58501, United States

Contact Phone: •••-•••-••••
Southern Cancer Center, PC
RECRUITING

Daphne, Alabama, 36526, United States

Contact Phone: •••-•••-••••
Swedish Cancer Institute - Edmonds
RECRUITING

Edmonds, Washington, 98026, United States

Contact Phone: •••-•••-••••
Swedish Medical Center
RECRUITING

Seattle, Washington, 98104, United States

Contact Phone: •••-•••-••••
Texas Oncology - Central/South Texas
RECRUITING

Austin, Texas, 78705, United States

Contact Phone: •••-•••-••••
Texas Oncology - Northeast Texas
RECRUITING

Tyler, Texas, 75702, United States

Contact Phone: •••-•••-••••
Thoraxklinik-Heidelberg gGmbH
RECRUITING

Heidelberg, 69126, Germany

Contact Phone: •••-•••-••••
University of New Mexico Comprehensive Cancer Center
RECRUITING

Albuquerque, New Mexico, 87106, United States

Contact Phone: •••-•••-••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

BMS-986489 (a combination of two drugs: BMS-986012 and nivolumab)

What this could lead to

If successful, this could offer a new first-line treatment option for people with extensive-stage small cell lung cancer, potentially improving survival compared to current therapy.

What could go wrong

This is an early-stage comparison against an already approved treatment. The new combination may not prove more effective or could have unexpected side effects. Results are years away.

Conditions

The condition(s) this trial relates to.

small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTENSIVE STAGE SMALL CELL LUNG CANCER EXTENSIVE-STAGE SMALL CELL LUNG CANCER