New PET tracers could illuminate immune battle inside lung tumors

NCT ID NCT06457789

First seen Aug 18, 2026 ยท Last updated Aug 18, 2026

Summary

This trial is testing two experimental PET imaging tracers to see if they can show T cell activity in lung cancer tumors. People with non-small cell lung cancer who are about to have surgery after standard chemo-immunotherapy will receive two PET scans. The scans will be compared to each other and to the removed tumor tissue to see if the tracers accurately reflect immune cell presence and activation. The goal is to find better ways to predict how well immunotherapy works.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Two experimental PET imaging tracers, [18F]F-AraG and [89Zr]Zr-Df-Crefmirlimab, are injected to visualize T cells in tumors.
What this could lead to
If successful, this could lead to better imaging methods to predict which lung cancer patients will respond to immunotherapy, enabling more personalized treatment.
What could go wrong
This is an early-stage imaging study with a small number of patients. The tracers may not accurately reflect immune activity, and results may not translate to broader clinical use.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Amsterdam UMC, location VUmc

    RECRUITING

    Amsterdam, North Holland, 1081 HV, Netherlands

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