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Can less radiation be just as good for hodgkin lymphoma?

NCT ID NCT07256158

Not yet recruiting Disease control Sponsor: Fondazione Italiana Linfomi - ETS Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether a lower dose of radiation (20 Gy) is as effective as the standard dose (30 Gy) for people with early-stage, unfavorable Hodgkin lymphoma. Only patients whose cancer shows a complete metabolic response after two cycles of chemotherapy will be included. The goal is to reduce side effects while maintaining the same level of cancer control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Radiation therapy (involved site radiotherapy)
What this could lead to
If successful, this could allow many Hodgkin lymphoma patients to receive a lower, safer dose of radiation without reducing the chance of keeping the cancer from coming back.
What could go wrong
This is a non-inferiority trial, so the lower dose might prove slightly less effective. The results apply only to patients who already had a good response to two cycles of chemotherapy, not everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

classic Hodgkin lymphoma Hodgkins lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HODGKIN LYMPHOMA

Contacts and locations

Locations

  • A.O. Ospedale S. Maria della Misericordia - Ematologia

    Perugia, Italy

  • A.O. Ospedali Riuniti Villa Sofia-Cervello - Divisione di Ematologia

    Palermo, Italy

  • A.O. S. Croce e Carle - S.C. Ematologia

    Cuneo, Italy

  • A.O. Santa Maria - S.C. Oncoematologia

    Terni, Italy

  • A.O.R.N. G Moscati - U.O.C. Ematologia e Terapie cellulari avanzate

    Avellino, Italy

  • A.O.U. Città della Salute e della Scienza di Torino - S.C. Ematologia

    Torino, Italy

  • A.O.U. Città della Salute e della Scienza di Torino - S.C. Ematologia U

    Torino, Italy

  • A.O.U. Ospedale Maggiore della Carità - S.C.D.U. Ematologia

    Novara, Italy

  • A.O.U. Policlinico Umberto I - U.O.C Ematologia

    Roma, Italy

  • A.O.U. SS. Antonio e Biagio e C. Arrigo - S.C.D.U. Ematologia

    Alessandria, Italy

  • A.O.U. Sant'Andrea - U.O.C. Ematologia

    Roma, Italy

  • A.O.U. Senese - U.O.C. Ematologia

    Siena, Italy

  • A.O.U. di Padova - U.O.C. Ematologia

    Padova, Italy

  • A.O.U.I. di Verona - U.O.C. Ematologia

    Verona, Italy

  • A.S.L. Toscana Centro - SOC Oncoematologia

    Florence, Italy

  • A.S.U. Friuli Centrale - Clinica Ematologica

    Udine, Italy

  • A.S.U. Giuliano Isontina - S.C. Ematologia

    Trieste, Italy

  • ARNAS "Brotzu" P.O. Businco - S.C. Ematologia e TMO

    Cagliari, Italy

  • ARNAS Garibaldi - U.O.C. Ematologia

    Catania, Italy

  • ASL Latina Ospedale S. Maria Goretti - UOC Ematologia con trapianto

    Latina, Italy

  • ASST Grande Ospedale Metropolitano Niguarda - S.C. Ematologia

    Milan, Italy

  • ASST Papa Giovanni XXIII - S.C. Ematologia

    Bergamo, Italy

  • ASST Spedali Civili - S.C. Ematologia

    Brescia, Italy

  • AUSL IRCCS Arcispedale S. Maria Nuova - S.C. Ematologia

    Reggio Emilia, Italy

  • AUSL di Piacenza Ospedale Guglielmo da Saliceto - U.O.C. Ematologia e centro trapianti

    Piacenza, Italy

  • AUSL di Ravenna Osp. S. Maria delle Croci - U.O.C. Ematologia

    Ravenna, Italy

  • Azienda Ospedaliera Universitaria Careggi - Unità funzionale di Ematologia

    Florence, Italy

  • Clinica Humanitas Gavazzeni - U.O. Oncologia Medica

    Bergamo, Italy

  • Fondazione Policlinico Campus Bio-Medico - U.O.C. Ematologia e trapianto di cellule staminali

    Roma, Italy

  • I.R.C.C.S. Istituto Oncologico Veneto - U.O.C. Oncologia 1

    Padova, Italy

  • I.R.C.C.S. Istituto di Candiolo - FPO

    Candiolo, Italy

  • IRCCS Centro Riferimento Oncologico - S.O.C. Oncologia medica e dei tumori immuno-correlati

    Aviano, Italy

  • IRCCS Fondazione Casa Sollievo della Sofferenza - UOC Ematologia e Trapianto di Cellule Staminali Ematopoietiche

    San Giovanni Rotondo, Italy

  • IRCCS Fondazione Istituto Nazionale Tumori - S.C. Ematologia

    Milan, Italy

  • IRCCS Fondazione Policlinico S. Matteo - S.C. Ematologia 1

    Pavia, Italy

  • IRCCS Humanitas - U.O. Ematologia

    Rozzano, Italy

  • IRCCS Policlinico S. Martino - U.O. Ematologia e terapie cellulari

    Genova, Italy

  • ULSS 2 Ospedale Ca' Foncello - U.O.C. Ematologia

    Treviso, Italy

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