Can less radiation be just as good for hodgkin lymphoma?
NCT ID NCT07256158
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial is testing whether a lower dose of radiation (20 Gy) is as effective as the standard dose (30 Gy) for people with early-stage, unfavorable Hodgkin lymphoma. Only patients whose cancer shows a complete metabolic response after two cycles of chemotherapy will be included. The goal is to reduce side effects while maintaining the same level of cancer control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Radiation therapy (involved site radiotherapy)
What this could lead to
If successful, this could allow many Hodgkin lymphoma patients to receive a lower, safer dose of radiation without reducing the chance of keeping the cancer from coming back.
What could go wrong
This is a non-inferiority trial, so the lower dose might prove slightly less effective. The results apply only to patients who already had a good response to two cycles of chemotherapy, not everyone.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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A.O. Ospedale S. Maria della Misericordia - Ematologia
Perugia, Italy
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A.O. Ospedali Riuniti Villa Sofia-Cervello - Divisione di Ematologia
Palermo, Italy
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A.O. S. Croce e Carle - S.C. Ematologia
Cuneo, Italy
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A.O. Santa Maria - S.C. Oncoematologia
Terni, Italy
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A.O.R.N. G Moscati - U.O.C. Ematologia e Terapie cellulari avanzate
Avellino, Italy
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A.O.U. Città della Salute e della Scienza di Torino - S.C. Ematologia
Torino, Italy
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A.O.U. Città della Salute e della Scienza di Torino - S.C. Ematologia U
Torino, Italy
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A.O.U. Ospedale Maggiore della Carità - S.C.D.U. Ematologia
Novara, Italy
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A.O.U. Policlinico Umberto I - U.O.C Ematologia
Roma, Italy
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A.O.U. SS. Antonio e Biagio e C. Arrigo - S.C.D.U. Ematologia
Alessandria, Italy
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A.O.U. Sant'Andrea - U.O.C. Ematologia
Roma, Italy
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A.O.U. Senese - U.O.C. Ematologia
Siena, Italy
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A.O.U. di Padova - U.O.C. Ematologia
Padova, Italy
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A.O.U.I. di Verona - U.O.C. Ematologia
Verona, Italy
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A.S.L. Toscana Centro - SOC Oncoematologia
Florence, Italy
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A.S.U. Friuli Centrale - Clinica Ematologica
Udine, Italy
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A.S.U. Giuliano Isontina - S.C. Ematologia
Trieste, Italy
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ARNAS "Brotzu" P.O. Businco - S.C. Ematologia e TMO
Cagliari, Italy
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ARNAS Garibaldi - U.O.C. Ematologia
Catania, Italy
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ASL Latina Ospedale S. Maria Goretti - UOC Ematologia con trapianto
Latina, Italy
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ASST Grande Ospedale Metropolitano Niguarda - S.C. Ematologia
Milan, Italy
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ASST Papa Giovanni XXIII - S.C. Ematologia
Bergamo, Italy
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ASST Spedali Civili - S.C. Ematologia
Brescia, Italy
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AUSL IRCCS Arcispedale S. Maria Nuova - S.C. Ematologia
Reggio Emilia, Italy
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AUSL di Piacenza Ospedale Guglielmo da Saliceto - U.O.C. Ematologia e centro trapianti
Piacenza, Italy
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AUSL di Ravenna Osp. S. Maria delle Croci - U.O.C. Ematologia
Ravenna, Italy
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Azienda Ospedaliera Universitaria Careggi - Unità funzionale di Ematologia
Florence, Italy
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Clinica Humanitas Gavazzeni - U.O. Oncologia Medica
Bergamo, Italy
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Fondazione Policlinico Campus Bio-Medico - U.O.C. Ematologia e trapianto di cellule staminali
Roma, Italy
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I.R.C.C.S. Istituto Oncologico Veneto - U.O.C. Oncologia 1
Padova, Italy
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I.R.C.C.S. Istituto di Candiolo - FPO
Candiolo, Italy
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IRCCS Centro Riferimento Oncologico - S.O.C. Oncologia medica e dei tumori immuno-correlati
Aviano, Italy
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IRCCS Fondazione Casa Sollievo della Sofferenza - UOC Ematologia e Trapianto di Cellule Staminali Ematopoietiche
San Giovanni Rotondo, Italy
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IRCCS Fondazione Istituto Nazionale Tumori - S.C. Ematologia
Milan, Italy
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IRCCS Fondazione Policlinico S. Matteo - S.C. Ematologia 1
Pavia, Italy
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IRCCS Humanitas - U.O. Ematologia
Rozzano, Italy
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IRCCS Policlinico S. Martino - U.O. Ematologia e terapie cellulari
Genova, Italy
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ULSS 2 Ospedale Ca' Foncello - U.O.C. Ematologia
Treviso, Italy
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