Personalized vaccine shows promise in fighting melanoma recurrence
NCT ID NCT03897881
First seen Dec 08, 2025 · Last updated May 05, 2026 · Updated 15 times
Summary
This study tests whether adding a personalized cancer vaccine (mRNA-4157) to standard immunotherapy (pembrolizumab) can better prevent melanoma from coming back after surgery. About 267 people with high-risk melanoma that has spread to lymph nodes will receive either the vaccine plus pembrolizumab or pembrolizumab alone. The goal is to see if the combination improves how long people stay cancer-free.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Affinity Clinical Research
Murdoch, Western Australia, 6150, Australia
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Angeles Clinic and Research Institute
Santa Monica, California, 90404, United States
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California Pacific Medical Center Research Institute -CPMCRI
San Francisco, California, 94115, United States
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Dana Farber Cancer Institute
Boston, Massachusetts, 02115, United States
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Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
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Lombardi Cancer Center
Washington D.C., District of Columbia, 20007, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Melanoma Institute Australia
North Sydney, New South Wales, 2060, Australia
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NYU Langone Medical Center
New York, New York, 10016, United States
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Northside Hospital
Atlanta, Georgia, 30342, United States
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One Clinical Research Perth
Murdoch, Western Australia, 6150, Australia
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Orlando Health UF Health Cancer Center
Orlando, Florida, 32806, United States
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Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
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Providence Cancer Institute
Portland, Oregon, 97213, United States
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Sarah Cannon Cancer Center
Nashville, Tennessee, 37203, United States
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Smilow Cancer Center at Yale New Haven Hospital
New Haven, Connecticut, 06520, United States
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St John of God Hospital Subiaco
Subiaco, Western Australia, 6008, Australia
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Texas Oncology PA
Dallas, Texas, 75246, United States
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UPMC Hillman Cancer Center
Chicago, Illinois, 60637, United States
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University of Arizona
Tucson, Arizona, 85719, United States
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University of Colorado Cancer Center
Aurora, Colorado, 80045, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Westmead Hospital
Westmead, New South Wales, 2145, Australia
Conditions
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