Could a genetic test spare young breast cancer patients from chemo?

NCT ID NCT07106632

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 27 times

Summary

This study looks at whether a genetic test (Prosigna®) can help decide if younger women with a common type of early breast cancer need chemotherapy. About 3380 premenopausal women will be randomly assigned to either standard treatment (always chemo plus hormone therapy) or a test-guided approach where some may get only hormone therapy. The goal is to see if the test-guided approach works just as well while reducing side effects and improving quality of life.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

Locations

  • "OSPEDALE P. PEDERZOLI" Casa di Cura Privata S.p.A.

    Peschiera del Garda, 37019, Italy

  • A.O. di Perugia - Ospedale S. Maria della Misericordia

    Perugia, 06132, Italy

  • A.O.U Policlinico di Modena

    Modena, 41124, Italy

  • A.O.U. Federico II - Policlinico

    Naples, 80131, Italy

  • A.O.U. Policlinico Umberto I

    Roma, 00161, Italy

  • A.O.U. di Parma

    Parma, 43126, Italy

  • ASS Territoriale Papa Giovanni XXIII

    Bergamo, 24127, Italy

  • ASST Lecco - P.O. A. Manzoni

    Lecco, 23900, Italy

  • ASST Ospedale Maggiore di Crema

    Crema, 26013, Italy

  • AUSL - IRCCS di Reggio Emilia

    Reggio Emilia, 420123, Italy

  • AUSL Della Romagna

    Ravenna, 48121, Italy

  • AUSL della Romagna - Ospedale Infermi di Rimini

    Rimini, 47923, Italy

  • AUSL di Modena - Ospedale B. Ramazzini

    Carpi, 41012, Italy

  • Althaia Xarxa Assistencial Universitaria De Manresa Fundacio Privada

    Manresa, 08243, Spain

  • Avicenne Hospital (APHP)

    Bobigny, 93000, France

  • Azienda Ospedaliero Universitaria Careggi

    Florence, 50134, Italy

  • CH Annecy Genevois

    Épagny Metz-Tessy, 74370, France

  • CH Cholet

    Cholet, 49300, France

  • CHR Verviers

    Verviers, 4800, Belgium

  • CHU Helora Hôpital de La Louvière - Site Jolimont

    Haine-Saint-Paul, 7100, Belgium

  • CHU Tours

    Tours, 37000, France

  • CHU UCL Namur - Site Sainte Elisabeth

    Namur, 5000, Belgium

  • CHU de Limoges

    Limoges, 87042, France

  • CHU de Saint Etienne

    Saint-Priest-en-Jarez, 42000, France

  • CLCC Eugène Marquis

    Rennes, 35042, France

  • Centre Francois Baclesse

    Caen, 14000, France

  • Centre Georges François Leclerc

    Dijon, 21000, France

  • Centre Henri Becquerel

    Rouen, 76000, France

  • Centre Hospitalier Fleyriat Bourg en Bresse

    Bourg-en-Bresse, 01012, France

  • Centre Hospitalier Intercommunal de Fréjus Saint Raphael

    Fréjus, 83600, France

  • Centre Hospitalier Le Mans - Centre De Cancérologie De La Sarthe

    Le Mans, 72000, France

  • Centre Hospitalier Métropole Savoie

    Chambéry, 73000, France

  • Centre Hospitalier Simone Veil de Beauvais

    Beauvais, 60021, France

  • Centre Hospitalier d'Auxerre

    Auxerre, 89000, France

  • Centre Hospitalier de Pau

    Pau, 64000, France

  • Centre Hospitalier de la Côte Basque

    Bayonne, 64100, France

  • Centre Jean Perrin

    Clermont-Ferrand, 63011, France

  • Centre Léon Bérard

    Lyon, 69008, France

  • Centre Léonard De Vinci

    Dechy, 59187, France

  • Centre Oscar Lambret

    Lille, 59000, France

  • Centre de cancérologie Les Dentellières

    Valenciennes, 59300, France

  • Centro Di Riferimento Oncologico Di Aviano

    Aviano, 33081, Italy

  • Clinique Mutualiste de l'Estuaire

    Saint-Nazaire, 44600, France

  • Clinique Médico Chirurgicale Charcot

    Sainte-Foy-lès-Lyon, 69110, France

  • Clinique Pasteur

    Toulouse, 31076, France

  • Clinique Pasteur - CFRO

    Brest, 29200, France

  • Clinique Saint Pierre

    Ottignies, 1340, Belgium

  • Clinique Tivoli

    Bordeaux, 33000, France

  • Cliniques Universitaires Saint-Luc

    Brussels, 1200, Belgium

  • Consorcio Hospitalario Provincial De Castellon

    Castillón, 12006, Spain

  • Cork University Hospital

    Cork, T12 DC4A, Ireland

  • Fondazione IRCCS Istituto Nazionale Dei Tumori

    Milan, 20133, Italy

  • Fondazione Policlinico Universitario Agostino Gemelli IRCCS

    Roma, 00168, Italy

  • Grand Hôpital de Charleroi

    Charleroi, B-6060, Belgium

  • Groupe Hospitalier Mutualiste de Grenoble

    Grenoble, 38028, France

  • Groupement Hospitalier Est - Hospices Civils de Lyon

    Bron, 69500, France

  • Hospital Clinic De Barcelona

    Barcelona, 08036, Spain

  • Hospital General Universitario De Valencia

    Valencia, 46014, Spain

  • Hospital General Universitario Dr. Balmis

    Alicante, 03010, Spain

  • Hospital Universitario Ramon Y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Virgen De La Macarena

    Seville, 41009, Spain

  • Hospital Universitario Virgen De Las Nieves

    Granada, 18014, Spain

  • Hygeia Hospital

    Athens, GR 151 23, Greece

  • Hôpital Européen

    Marseille, 13003, France

  • Hôpital Lyon Sud-Hospices Civils de Lyon

    Pierre-Bénite, 69495, France

  • Hôpital NOVO - Site de Pontoise

    Pontoise, 95300, France

  • Hôpital Privé Clairval

    Marseille, 13009, France

  • Hôpital Privé Nancy Lorraine

    Nancy, 54000, France

  • Hôpital Privé du Confluent

    Nantes, 44277, France

  • Hôpital de Blois

    Blois, 41000, France

  • Hôpital de la croix Rousse - Hospices Civils de Lyon

    Lyon, 69004, France

  • Hôpitaux du Léman

    Thonon-les-Bains, 74200, France

  • IASO Hospital

    Athens, GR 151 23, Greece

  • IRCCS Istituto Nazionale Tumori Fondazione Pascale

    Naples, 80131, Italy

  • IRCCS Istituto Romagnolo per lo Studio Dei Tumori (IRST) "Dino Amadori"

    Meldola, 47014, Italy

  • IRCCS Ospedale Policlinico San Martino

    Genova, 16132, Italy

  • IRCCS San Gerardo

    Monza, 20900, Italy

  • Institut Godinot

    Reims, 51100, France

  • Institut Gustave Roussy

    Villejuif, 94800, France

  • Institut Jules Bordet

    Brussels, 1070, Belgium

  • Institut Paoli Calmettes

    Marseille, 13009, France

  • Institut de Cancérologie de Lorraine

    Vandœuvre-lès-Nancy, 54519, France

  • Instytut Centrum Zdrowia Matki Polki

    Lodz, 93-338, Poland

  • Istituto Oncologico Veneto

    Padova, 35128, Italy

  • Klinika Onkologii I Radioterapii Universeryteckie Centrum Kliniczne- Gdansk

    Gdansk, 80-214, Poland

  • MSC National Research Institute Of Oncology

    Gliwice, 44-102, Poland

  • Mater Misericordiae University Hospital

    Dublin, D07 A8NN, Ireland

  • Mater Private Hospital

    Dublin, D07 WKW8, Ireland

  • Metropolitan Hospital

    Athens, GR 185 47, Greece

  • Midland Regional Hospital Tullamore

    Tullamore, R35 NY51, Ireland

  • Militray Institute of Medicine

    Warsaw, 04-141, Poland

  • Oncology Clinic, University Clinical Hospital in Pozan, Medical University

    Poznan, 60-569, Poland

  • Oncopole Claudius Regaud, IUCT-Oncopole

    Toulouse, 31059, France

  • Pôle Santé République

    Clermont-Ferrand, 63000, France

  • Sainte Catherine - Institut du Cancer Avignon-Provence

    Avignon, 84918, France

  • St James's Hospital

    Dublin, D08 NHY1, Ireland

  • Strasbourg Oncologie Libérale - Clinique Sainte Anne

    Strasbourg, 67000, France

  • University General Hospital 'Attikon'

    Athens, GR 124 62, Greece

  • University Hospital 'Aretaieio'

    Athens, GR 115 28, Greece

  • University Hospital Limerick

    Limerick, V94 F858, Ireland

  • University Hospital Son Espases

    Palma, 07120, Spain

  • University Hospital Virgen Del Rocio

    Seville, 41013, Spain

  • University Hospital Waterford

    Waterford, X91 ER8E, Ireland

  • ZP ZOZ Opolskie Centrum Onkologii im.prof. Tadeusza Koszarowskiego

    Opole, 45-061, Poland

  • Zachodniopomorskie Centrum Onkologii

    Szczecin, 71-730, Poland

Conditions

Explore the condition pages connected to this study.