Could a genetic test spare young breast cancer patients from chemo?
NCT ID NCT07106632
First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 27 times
Summary
This study looks at whether a genetic test (Prosigna®) can help decide if younger women with a common type of early breast cancer need chemotherapy. About 3380 premenopausal women will be randomly assigned to either standard treatment (always chemo plus hormone therapy) or a test-guided approach where some may get only hormone therapy. The goal is to see if the test-guided approach works just as well while reducing side effects and improving quality of life.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for HR+/HER2- BREAST CANCER are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Locations
-
"OSPEDALE P. PEDERZOLI" Casa di Cura Privata S.p.A.
Peschiera del Garda, 37019, Italy
-
A.O. di Perugia - Ospedale S. Maria della Misericordia
Perugia, 06132, Italy
-
A.O.U Policlinico di Modena
Modena, 41124, Italy
-
A.O.U. Federico II - Policlinico
Naples, 80131, Italy
-
A.O.U. Policlinico Umberto I
Roma, 00161, Italy
-
A.O.U. di Parma
Parma, 43126, Italy
-
ASS Territoriale Papa Giovanni XXIII
Bergamo, 24127, Italy
-
ASST Lecco - P.O. A. Manzoni
Lecco, 23900, Italy
-
ASST Ospedale Maggiore di Crema
Crema, 26013, Italy
-
AUSL - IRCCS di Reggio Emilia
Reggio Emilia, 420123, Italy
-
AUSL Della Romagna
Ravenna, 48121, Italy
-
AUSL della Romagna - Ospedale Infermi di Rimini
Rimini, 47923, Italy
-
AUSL di Modena - Ospedale B. Ramazzini
Carpi, 41012, Italy
-
Althaia Xarxa Assistencial Universitaria De Manresa Fundacio Privada
Manresa, 08243, Spain
-
Avicenne Hospital (APHP)
Bobigny, 93000, France
-
Azienda Ospedaliero Universitaria Careggi
Florence, 50134, Italy
-
CH Annecy Genevois
Épagny Metz-Tessy, 74370, France
-
CH Cholet
Cholet, 49300, France
-
CHR Verviers
Verviers, 4800, Belgium
-
CHU Helora Hôpital de La Louvière - Site Jolimont
Haine-Saint-Paul, 7100, Belgium
-
CHU Tours
Tours, 37000, France
-
CHU UCL Namur - Site Sainte Elisabeth
Namur, 5000, Belgium
-
CHU de Limoges
Limoges, 87042, France
-
CHU de Saint Etienne
Saint-Priest-en-Jarez, 42000, France
-
CLCC Eugène Marquis
Rennes, 35042, France
-
Centre Francois Baclesse
Caen, 14000, France
-
Centre Georges François Leclerc
Dijon, 21000, France
-
Centre Henri Becquerel
Rouen, 76000, France
-
Centre Hospitalier Fleyriat Bourg en Bresse
Bourg-en-Bresse, 01012, France
-
Centre Hospitalier Intercommunal de Fréjus Saint Raphael
Fréjus, 83600, France
-
Centre Hospitalier Le Mans - Centre De Cancérologie De La Sarthe
Le Mans, 72000, France
-
Centre Hospitalier Métropole Savoie
Chambéry, 73000, France
-
Centre Hospitalier Simone Veil de Beauvais
Beauvais, 60021, France
-
Centre Hospitalier d'Auxerre
Auxerre, 89000, France
-
Centre Hospitalier de Pau
Pau, 64000, France
-
Centre Hospitalier de la Côte Basque
Bayonne, 64100, France
-
Centre Jean Perrin
Clermont-Ferrand, 63011, France
-
Centre Léon Bérard
Lyon, 69008, France
-
Centre Léonard De Vinci
Dechy, 59187, France
-
Centre Oscar Lambret
Lille, 59000, France
-
Centre de cancérologie Les Dentellières
Valenciennes, 59300, France
-
Centro Di Riferimento Oncologico Di Aviano
Aviano, 33081, Italy
-
Clinique Mutualiste de l'Estuaire
Saint-Nazaire, 44600, France
-
Clinique Médico Chirurgicale Charcot
Sainte-Foy-lès-Lyon, 69110, France
-
Clinique Pasteur
Toulouse, 31076, France
-
Clinique Pasteur - CFRO
Brest, 29200, France
-
Clinique Saint Pierre
Ottignies, 1340, Belgium
-
Clinique Tivoli
Bordeaux, 33000, France
-
Cliniques Universitaires Saint-Luc
Brussels, 1200, Belgium
-
Consorcio Hospitalario Provincial De Castellon
Castillón, 12006, Spain
-
Cork University Hospital
Cork, T12 DC4A, Ireland
-
Fondazione IRCCS Istituto Nazionale Dei Tumori
Milan, 20133, Italy
-
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Roma, 00168, Italy
-
Grand Hôpital de Charleroi
Charleroi, B-6060, Belgium
-
Groupe Hospitalier Mutualiste de Grenoble
Grenoble, 38028, France
-
Groupement Hospitalier Est - Hospices Civils de Lyon
Bron, 69500, France
-
Hospital Clinic De Barcelona
Barcelona, 08036, Spain
-
Hospital General Universitario De Valencia
Valencia, 46014, Spain
-
Hospital General Universitario Dr. Balmis
Alicante, 03010, Spain
-
Hospital Universitario Ramon Y Cajal
Madrid, 28034, Spain
-
Hospital Universitario Virgen De La Macarena
Seville, 41009, Spain
-
Hospital Universitario Virgen De Las Nieves
Granada, 18014, Spain
-
Hygeia Hospital
Athens, GR 151 23, Greece
-
Hôpital Européen
Marseille, 13003, France
-
Hôpital Lyon Sud-Hospices Civils de Lyon
Pierre-Bénite, 69495, France
-
Hôpital NOVO - Site de Pontoise
Pontoise, 95300, France
-
Hôpital Privé Clairval
Marseille, 13009, France
-
Hôpital Privé Nancy Lorraine
Nancy, 54000, France
-
Hôpital Privé du Confluent
Nantes, 44277, France
-
Hôpital de Blois
Blois, 41000, France
-
Hôpital de la croix Rousse - Hospices Civils de Lyon
Lyon, 69004, France
-
Hôpitaux du Léman
Thonon-les-Bains, 74200, France
-
IASO Hospital
Athens, GR 151 23, Greece
-
IRCCS Istituto Nazionale Tumori Fondazione Pascale
Naples, 80131, Italy
-
IRCCS Istituto Romagnolo per lo Studio Dei Tumori (IRST) "Dino Amadori"
Meldola, 47014, Italy
-
IRCCS Ospedale Policlinico San Martino
Genova, 16132, Italy
-
IRCCS San Gerardo
Monza, 20900, Italy
-
Institut Godinot
Reims, 51100, France
-
Institut Gustave Roussy
Villejuif, 94800, France
-
Institut Jules Bordet
Brussels, 1070, Belgium
-
Institut Paoli Calmettes
Marseille, 13009, France
-
Institut de Cancérologie de Lorraine
Vandœuvre-lès-Nancy, 54519, France
-
Instytut Centrum Zdrowia Matki Polki
Lodz, 93-338, Poland
-
Istituto Oncologico Veneto
Padova, 35128, Italy
-
Klinika Onkologii I Radioterapii Universeryteckie Centrum Kliniczne- Gdansk
Gdansk, 80-214, Poland
-
MSC National Research Institute Of Oncology
Gliwice, 44-102, Poland
-
Mater Misericordiae University Hospital
Dublin, D07 A8NN, Ireland
-
Mater Private Hospital
Dublin, D07 WKW8, Ireland
-
Metropolitan Hospital
Athens, GR 185 47, Greece
-
Midland Regional Hospital Tullamore
Tullamore, R35 NY51, Ireland
-
Militray Institute of Medicine
Warsaw, 04-141, Poland
-
Oncology Clinic, University Clinical Hospital in Pozan, Medical University
Poznan, 60-569, Poland
-
Oncopole Claudius Regaud, IUCT-Oncopole
Toulouse, 31059, France
-
Pôle Santé République
Clermont-Ferrand, 63000, France
-
Sainte Catherine - Institut du Cancer Avignon-Provence
Avignon, 84918, France
-
St James's Hospital
Dublin, D08 NHY1, Ireland
-
Strasbourg Oncologie Libérale - Clinique Sainte Anne
Strasbourg, 67000, France
-
University General Hospital 'Attikon'
Athens, GR 124 62, Greece
-
University Hospital 'Aretaieio'
Athens, GR 115 28, Greece
-
University Hospital Limerick
Limerick, V94 F858, Ireland
-
University Hospital Son Espases
Palma, 07120, Spain
-
University Hospital Virgen Del Rocio
Seville, 41013, Spain
-
University Hospital Waterford
Waterford, X91 ER8E, Ireland
-
ZP ZOZ Opolskie Centrum Onkologii im.prof. Tadeusza Koszarowskiego
Opole, 45-061, Poland
-
Zachodniopomorskie Centrum Onkologii
Szczecin, 71-730, Poland
Conditions
Explore the condition pages connected to this study.