New study tests if a collagen wrap boosts bone graft success for infected implants

NCT ID NCT05699343

ENROLLING_BY_INVITATION Disease control Sponsor: Andrea Ravida Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two surgical treatments for peri-implantitis, a serious gum infection around dental implants. Fifty-two adults will receive either a bone graft alone or a bone graft covered with a resorbable collagen membrane. The goal is to see which method better stops infection, reduces pocket depth, and restores bone loss around the implant over five years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Bone graft (InterOss Collagen) and collagen membrane (InterOss Collagen Guide)
What this could lead to: If it works, this could show that adding a collagen membrane over a bone graft improves the success rate of treating peri-implantitis, helping to save infected dental implants.
What could go wrong: This is a small, early-stage trial with only 52 participants, so results may not apply to everyone. The treatment is surgical and carries risks like infection, implant failure, or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Peri-Implantitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERI IMPLANTITIS SURGERY

Contacts and locations

Locations

University of Pittsburgh School of Dental Medicine

Pittsburgh, Pennsylvania, 15213, United States

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