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Can a Cow-Bone graft save failing dental implants?

NCT ID NCT07809334

Disease control Sponsor: University of Turin, Italy Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Peri-implantitis is an infection that destroys bone around dental implants and can cause them to loosen or fall out. Researchers at the University of Turin are following 75 patients who had reconstructive surgery for this condition. Surgeons cleaned the infected implant, treated its surface, and filled the bone defect with a graft made from deproteinized bovine bone mineral plus collagen. The study measures how many treated implants remain in place over 10 years and whether the shape of the defect affects survival.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A bone graft material made from deproteinized bovine bone mineral with 10% collagen, placed into jawbone defects around dental implants
What this could lead to
If the graft holds up, it could give dentists a reliable way to save dental implants that would otherwise be removed because of peri-implantitis.
What could go wrong
This is a single-center observational study of 75 people, so results may not apply to all implant patients or defect types. Some implants may still fail despite surgery, and the graft adds cost and healing time.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 75 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Subjects rehabilitated with oral dental implants who presented a single peri-implantitis crater-like lesion with a PD of ≥6 mm

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients rehabilitated with oral dental implants affected by peri-implantitis * A single peri-implantitis crater-like lesion with a Probing depth ofof ≥6 mm * No implant mobility, * Smokers Exclusion Criteria: * Probing depth \<6 mm; * Class II defects (characterized by consistent horizontal bone loss); * Multiple defects; * Implant mobility; * Subjects not interested in participating in the study;

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Conditions

The condition(s) this trial relates to.

Peri-Implantitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Peri-implantitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

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  3. A doctor treating you

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Contacts and locations

Locations

  • S.C. Chirurgia Maxillo-facciale U

    Torino, Italy

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