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Can a bone graft rescue failing dental implants?

NCT ID NCT03077061

Disease control Sponsor: Göteborg University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Peri-implantitis is an infection that destroys bone around dental implants. Researchers are testing whether adding a bone replacement graft to standard open flap surgery improves treatment success compared with surgery alone. The trial enrolls 140 healthy adults with at least one affected implant and follows them for five years across seven clinics.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a bone replacement graft made of collagen and bone mineral
What this could lead to
If the graft helps, it could become a standard addition to surgery for peri-implantitis, saving more dental implants from removal.
What could go wrong
The graft may not improve outcomes over surgery alone, and any benefit could fade over five years. Surgery carries risks of infection, bleeding, and further gum recession.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

140 people

The number who actually took part.

Started

Apr 2017

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * ≥1 implant (≥1 year of function) presenting with PPD ≥7 mm and BoP/Pus. * Confirmed bone loss ≥3 mm at same implant(s) Exclusion Criteria: * Treated for peri-implantitis during previous 6 months * Intake of systemic or local antibiotics during previous 6 months * Systemic conditions affecting peri-implant tissues * Systemic conditions impeding surgical intervention

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Conditions

The condition(s) this trial relates to.

Peri-Implantitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Peri-implantitis

Contacts and locations

Locations

  • Department of Periodontology, Institute of Odontology

    Gothenburg, 40530, Sweden

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