Could a simple drug combo heal jaw bone damage?
NCT ID NCT05795647
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether a combination of pentoxifylline and vitamin E can help heal jaw bone damage caused by certain osteoporosis or cancer drugs. The study will enroll 17 adults with stage 2 medication-related osteonecrosis of the jaw. Researchers will measure how many patients have less than 5 mm of exposed bone after 12 months of treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pentoxifylline and tocopherol (vitamin E)
What this could lead to
If it works, this could offer a new treatment option for people with jaw bone damage caused by certain medications, potentially reducing pain and improving quality of life.
What could go wrong
This is a small, early-phase trial with only 17 participants, so results may not apply to everyone. The treatment may not work better than current options, and side effects are possible.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Limoges university hospital
RECRUITINGLimoges, 87042, France
Contact Email: •••••@•••••
Contact