Can a triple-drug cocktail re-sensitize lung cancer to treatment?
NCT ID NCT05599789
First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether adding plinabulin to a standard combination of pembrolizumab and docetaxel can shrink tumors or slow disease progression in people with metastatic non-small cell lung cancer that has worsened after prior immunotherapy. About 47 adults with advanced squamous or non-squamous NSCLC will receive all three drugs intravenously every three weeks. The main goal is to see how many patients experience a significant tumor response.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a combination of pembrolizumab, plinabulin, and docetaxel
- What this could lead to
- If successful, this combination could offer a new treatment option for people with advanced lung cancer whose disease has worsened after standard immunotherapy.
- What could go wrong
- This is an early phase 2 trial with only 47 participants, so results may not apply broadly. Combining three drugs also raises the risk of serious side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital
Beijing, Beijing Municipality, 100730, China
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Other studies related to the condition(s) this trial covers.
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