New drug combo shows promise in Tough-to-Treat prostate cancer

NCT ID NCT04848337

First seen Feb 12, 2026 · Last updated May 22, 2026 · Updated 13 times

Summary

This study tests two drugs, pembrolizumab and lenvatinib, in 45 people with advanced neuroendocrine prostate cancer that has spread. The goal is to see if the combination can slow tumor growth. Treatment continues until the cancer worsens or side effects become too severe, for up to 35 cycles (about 2 years).

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • City of Hope

    Duarte, California, 91010, United States

  • Froedtert and The Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Oregon health

    Portland, Oregon, 97239, United States

  • University of Michigan Health System

    Ann Arbor, Michigan, 48109, United States

  • Winship Cancer Instituted of Emory University

    Atlanta, Georgia, 30322, United States

Conditions

Explore the condition pages connected to this study.