New hope for men with hard-to-treat prostate cancer: adding immunotherapy to existing drug

NCT ID NCT02312557

First seen Jan 02, 2026 · Last updated May 24, 2026 · Updated 19 times

Summary

This study tests whether adding the immunotherapy drug pembrolizumab can help men whose advanced prostate cancer has stopped responding to the hormone therapy enzalutamide. About 58 men with castration-resistant prostate cancer that has spread will receive pembrolizumab while continuing enzalutamide. The main goal is to see if PSA levels drop by at least half, indicating the cancer is being controlled.

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Contacts and locations

Locations

  • OHSU Knight Cancer Institute

    Portland, Oregon, 97239, United States

Conditions

Explore the condition pages connected to this study.