New hope for mystery cancers: immunotherapy shows promise

NCT ID NCT03752333

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested the immunotherapy drug pembrolizumab in 35 adults with cancer of unknown primary (CUP), a cancer that starts in an unknown location. Participants received the drug intravenously, and researchers measured how many saw their tumors shrink or disappear. The goal was to control the disease, not cure it, and the study is now complete.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary โ€” we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CANCER OF UNKNOWN PRIMARY SITE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cancer of unknown primary site carcinoma neoplasm Neoplasms, Unknown Primary

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Gastrointestinal Units, The Royal Marsden NHS Foundation Trust (Sutton and Chelsea)

    Sutton, Surrey, United Kingdom

  • Guy's Cancer Centre, Guy's and St Thomas' NHS Foundation Trust

    London, United Kingdom

  • Hammersmith Hospital - Imperial College Healthcare NHS Trust

    Hammersmith, London, W12 0HS, United Kingdom