Triple therapy shows promise in shrinking sarcomas before surgery

NCT ID NCT06128863

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests whether combining an immunotherapy drug (pembrolizumab) with another immune-boosting protein (eftilagimod alpha) and radiation therapy can shrink soft tissue sarcomas before surgery. About 40 adults with high-risk, non-spread sarcomas will receive this combination, then have their tumor removed to see how much of it has been destroyed. The goal is to improve outcomes, but ongoing monitoring and potential long-term treatment may still be needed.

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Conditions

The condition(s) this trial relates to.

sarcoma soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Maria Sklodowska-Curie National Research Institute of Oncology

    Warsaw, 00-738, Poland