New combo therapy shows promise for Hard-to-Treat breast cancer on chest wall

NCT ID NCT03095352

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tested whether adding the immunotherapy drug pembrolizumab to the chemotherapy drug carboplatin works better than carboplatin alone for breast cancer that has returned on the chest wall. The trial included 76 people with either triple-negative or hormone-resistant breast cancer. The main goal was to see if the combination could control the disease for at least 18 weeks.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Georgetown University Hospital

    Washington D.C., District of Columbia, 20007, United States

  • Indiana University/Melvin and Bren Simon Cancer Center

    Indianapolis, Indiana, 46202, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • University of California, San Francisco

    San Francisco, California, 94143, United States

  • University of Chicago Comprehensive Cancer Center

    Chicago, Illinois, 60637, United States

  • University of Pittsburgh Cancer Institute

    Pittsburgh, Pennsylvania, 15232, United States

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee, 37232, United States