Can a natural supplement shield the aging brain from Surgery's mental fog?
NCT ID NCT07681063
First seen Jul 02, 2026 · Last updated Jul 02, 2026
Summary
This study tests whether a combination of palmitoylethanolamide and luteolin (PEALut), taken as an oral supplement for three months after heart surgery, can help prevent or reduce cognitive decline in adults aged 65 and older. The supplement aims to calm brain inflammation and oxidative stress, which are thought to contribute to postoperative cognitive dysfunction. Participants will be randomly assigned to receive either the supplement plus standard care, or standard care alone, and their thinking abilities will be tracked using memory and attention tests.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Palmitoylethanolamide and Luteolin (PEALut) oral suspension
What this could lead to
If it works, this could offer a simple, safe supplement to help older adults maintain their memory and thinking after heart surgery.
What could go wrong
This is a small, early-stage trial. The supplement may not prevent cognitive decline, and results may not apply to all types of surgery or patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Ciprofol vs Propofol for Post-Op Cognition (NCT07673978)
- Iron Deficiency & Scoliosis Surgery Trial (NCT06042699)
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- Cognitive Decline After Gynecologic Surgery (NCT07589348)
- Caffeine for Post-Surgery Delirium: CAPACHINOS-2 NCT05574400
- S100B & Post-Surgery Brain Function Study (NCT07509372)
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Fondazione IRCCS San Gerardo dei Tintori
Monza, Italy
Contact Email: •••••@•••••