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Could a flower extract replace sedatives for tooth extraction fear?

NCT ID NCT07790029

Symptom relief Sponsor: Ömer faruk Kaygısız Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time

Summary

This trial tests whether a single dose of passionflower extract can reduce anxiety before tooth extraction. Men who report high anxiety before the procedure will receive either passionflower or a placebo, and neither they nor the researchers will know which. The study compares anxiety scores and physical signs like heart rate and blood pressure to see if this natural option could help people who fear dental work without using medication.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Passiflora incarnata extract (passionflower), given as a single 450 mg capsule before tooth extraction
What this could lead to
If it works, passionflower could offer a natural, drug-free way to calm people before dental procedures.
What could go wrong
This is a small, early trial in men only, and the effect may be no better than placebo. Passionflower can cause drowsiness or dizziness in some people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 58 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients presenting for dental extraction at Kahramanmaraş Sütçü İmam University Faculty of Dentistry Voluntary agreement to participate and signed informed consent State-Trait Anxiety Inventory (STAI) state anxiety score of 40 or above Male sex No general health disorder based on medical history and physical examination Exclusion Criteria: STAI state anxiety score below 40 Refusal to voluntarily participate in the study General health disorder based on medical history and physical examination Age under 18 years Female sex Known hypersensitivity to Passiflora incarnata Use of synthetic sedatives

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental anxiety Preoperative anxiety

Contacts and locations

Locations

  • Kahramanmaraş Sütçü İmam University Faculty of Dentistry

    Kahramanmaraş, TR, 46100, Turkey (Türkiye)

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