Heart valve repair showdown: new device challenges standard treatment

NCT ID NCT03706833

Ongoing Disease control Sponsor: Edwards Lifesciences Source: ClinicalTrials.gov ↗

Summary

This large study is comparing two different devices that repair a leaky mitral heart valve without open-heart surgery. It involves over 1,200 patients who are at high risk for surgery or have heart failure. The main goal is to see if the newer PASCAL device is as safe and effective as the established MitraClip device at reducing the leak and improving patients' lives.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Locations

Abrazo Arizona Heart Hospital

Phoenix, Arizona, 85016, United States
AdventHealth Orlando

Orlando, Florida, 32803, United States
Albany Medical College

Albany, New York, 12208, United States
Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212, United States
Aurora St. Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Banner University Medical Center

Phoenix, Arizona, 85006, United States
Baptist Memorial Hospital Memphis

Memphis, Tennessee, 38138, United States
Baylor College of Medicine

Houston, Texas, 77030, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Brigham and Woman's Hospital

Boston, Massachusetts, 02115, United States
CVA Heart Institute Kingsport

Kingsport, Tennessee, 37660, United States
Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Centennial Medical Center

Nashville, Tennessee, 37203, United States
CentraCare Heart and Vascular Center

Saint Cloud, Minnesota, 56303, United States
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (IUCPQ) ULaval

Québec, G1V 4G5, Canada
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Columbia University Medical Center/New York Presbyterian Hospital

New York, New York, 10032, United States
Emory University Hospital and Emory University Hospital Midtown

Atlanta, Georgia, 30322, United States
HCA Houston Healthcare Medical Center

Houston, Texas, 77004, United States
Hamilton Health Sciences

Hamilton, Ontario, L8L 2X2, Canada
Helios Klinikum Siegburg

Siegburg, 53721, Germany
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Herrzentrum Dresden GmbH Universitätklinik an der Technischen Universität Dresden

Dresden, 01307, Germany
Herzzentrum Leipzig Universitätsklinik für Kardiologie

Leipzig, 04289, Germany
Herzzentrum Universitätsklinikum Koln

Cologne, 50937, Germany
Hospital of the University of Pennsylvania/Penn Presbyterian Medical Center

Philadelphia, Pennsylvania, 19104, United States
Houston Methodist Hospital

Houston, Texas, 77030, United States
Intermountain Medical Center

Salt Lake City, Utah, 84107, United States
Kaiser Permanente San Francisco

San Francisco, California, 94118, United States
Klinik für Allgemeine und Interventionelle Kardiologie/Angiologie, Herz- und Diabeteszentrum NRW, Universitätsklinik der Ruhr-Universität Bochum

Bad Oeynhausen, 32545, Germany
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Lenox Hill Hospital and North Shore University

New York, New York, 10075, United States
Los Robles Hospital and Medical Center

Thousand Oaks, California, 91360, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Medical Center of the Rockies

Loveland, Colorado, 80538, United States
Medizinische Klinik I LMU München Campus Grosshadern

München, 81377, Germany
Medstar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Montefiore Medical Center

The Bronx, New York, 10467, United States
Montreal Heart Institute

Montreal, Quebec, H1T 1C8, Canada
Morristown Medical Center

Morristown, New Jersey, 07960, United States
Mount Sinai

Miami Beach, Florida, 33140, United States
NCH Rooney Heart Institute

Naples, Florida, 34102, United States
NYU Langone Health

New York, New York, 10016, United States
NYU Langone Hospital - Long Island

Mineola, New York, 11501, United States
Northwestern University

Chicago, Illinois, 60611, United States
Oklahoma Cardiovascular

Oklahoma City, Oklahoma, 73120, United States
Oklahoma Heart Institute

Tulsa, Oklahoma, 74104, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
Piedmont Healthcare

Atlanta, Georgia, 30309, United States
Pinnacle Health Cardiovascular Institute/ UPMC Pinnacle Harrisburg

Wormleysburg, Pennsylvania, 17043, United States
Rochester General Hospital

Rochester, New York, 14621, United States
Rutgers-RWJMS

New Brunswick, New Jersey, 08901, United States
Saint Thomas Heart at Saint Thomas West

Nashville, Tennessee, 37205, United States
Scripps Memorial Hospital La Jolla

La Jolla, California, 92071, United States
Sentara Norfolk General Hospital

Norfolk, Virginia, 23507, United States
St. Francis Hospital

Roslyn, New York, 11576, United States
St. Michael's Hospital

Toronto, Ontario, M5B 1W8, Canada
St. Pauls Hospital

Vancouver, British Columbia, V6E 1M7, Canada
St. Vincent Heart Center

Carmel, Indiana, 46290, United States
St.Luke's Hospital of Kansas City

Kansas City, Missouri, 64111, United States
Stanford University

Stanford, California, 94305, United States
State University of New York at Buffalo

Buffalo, New York, 14203, United States
Sutter Bay Area

San Francisco, California, 94109, United States
Sutter Medical Center-Sacramento

Sacramento, California, 95618, United States
Swedish Medical Center

Seattle, Washington, 98122, United States
TMC Healthcare

Tucson, Arizona, 85712, United States
The Cardiac and Vascular Institute Research Foundation

Gainesville, Florida, 32605, United States
The Christ Hospital

Cincinnati, Ohio, 45219-2906, United States
The Heart Hospital Baylor Plano

Plano, Texas, 75093, United States
The University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States
UC Irvine

Orange, California, 92868, United States
ULM University Zentrum für Innere Medizin Klinik für Innere Medizin II

Ulm, 89081, Germany
University Hospital Bern

Bern, 3010, Switzerland
University of California, San Francisco

San Francisco, California, 94143, United States
University of Iowa Hospitals & Clinics

Iowa City, Iowa, 52242, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Virginia

Charlottesville, Virginia, 22908, United States
Universitäres Herzzentrum Hamburg GmbH (UHZ) Klinik und Poliklinik für Allgemeneine und Interventionelle Kardiologie

Hamburg, 20246, Germany
Universitätsklinikum Essen (AöR) Klinik für Kardiologie und Angiologie am Westdeutschen Herz- und Gefäßzentrum

Essen, 45174, Germany
Universitätsklinikum Gießen Medizinische Klinik I, Innere Medizin/ Kardiologie

Giessen, 35392, Germany
Universitätsklinikum Heidelberg Klinik für Kardiologie, Angiologie, Pneumologie

Heidelberg, 69120, Germany
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Washington University/Barnes Jewish Hospital

St Louis, Missouri, 63110, United States
WellSpan York Hospital

York, Pennsylvania, 17405, United States
Zentrum für Kardiologie - Kardiologie I Universitätsmedizin der Johannes Gutenberg Universität Mainz

Mainz, 55131, Germany

Conditions

Explore the condition pages connected to this study.

DEGENERATIVE MITRAL VALVE DISEASE FUNCTIONAL MITRAL REGURGITATION MITRAL INSUFFICIENCY MITRAL REGURGITATION