New immunotherapy combo takes on tough pancreatic cancer

NCT ID NCT05630183

Completed Disease control Sponsor: Agenus Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tested whether adding an immunotherapy drug called botensilimab to standard chemotherapy could help people with metastatic pancreatic cancer who had already progressed on a common chemo regimen (FOLFIRINOX). The study enrolled 81 participants and compared the combination to chemotherapy alone. The goal was to see if the combination could slow cancer growth or improve survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: botensilimab (an immunotherapy drug) plus standard chemotherapy (nab-paclitaxel and gemcitabine)
What this could lead to: If it works, this could point toward a new treatment option for people with metastatic pancreatic cancer who have already tried standard chemotherapy.
What could go wrong: This is a small, early-phase trial (81 people) with no results yet. The drug may not improve outcomes and could cause additional side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pancreatic ductal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC PANCREATIC DUCTAL ADENOCARCINOMA

Contacts and locations

Locations

Atlantic Health Systems, Morristown

Morristown, New Jersey, 07960, United States
Baylor Charles A. Sammons Cancer Center

Dallas, Texas, 75247, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Cancer Care Centers of Brevard

Palm Bay, Florida, 32909, United States
Comprehensive Cancer Centers of Nevada - Summerlin Medical Center II*

Las Vegas, Nevada, 89144, United States
Florida Cancer Specialist North

St. Petersburg, Florida, 22705, United States
Florida Cancer Specialist South

Fort Myers, Florida, 33901, United States
HonorHealth

Scottsdale, Arizona, 85258, United States
Icahn School of Medicine at Mount Sinai Tisch Cancer Institute

New York, New York, 10128, United States
Illinois Cancer Specialists

Arlington Heights, Illinois, 60005, United States
John Theurer Cancer Center at Hackensack

Hackensack, New Jersey, 07601, United States
Lifespan

Providence, Rhode Island, 02903, United States
Maryland Oncology Hematology

Columbia, Maryland, 21044, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Medical Oncology Hematology Consultants (MOHC) - Helen F. Graham Cancer Center

Newark, Delaware, 19713, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Minnesota Oncology

Minneapolis, Minnesota, 55404, United States
Nebraska Medicine-Nebraska Medical Center

Omaha, Nebraska, 68198, United States
Northeast Texas Cancer & Research Institute

Tyler, Texas, 75702, United States
Oncology Hematology Care - Eastgate

Cincinnati, Ohio, 45245, United States
Overlook Medical Center

Summit, New Jersey, 07901, United States
Rogel Cancer Center, University of Michigan Medicine

Ann Arbor, Michigan, 48109, United States
Sarah Cannon Research Institute at Tennessee Oncology

Cincinnati, Ohio, 45245, United States
Sarah Cannon Research Institute at Tennessee Oncology

Nashville, Tennessee, 37203, United States
Shenandoah Oncology

Winchester, Virginia, 22601, United States
Swedish Cancer Institute

Seattle, Washington, 98104, United States
Texas Oncology

Carrollton, Texas, 75010, United States
The Center for Cancer & Blood Disorders: Fort Worth

Fort Worth, Texas, 76104, United States
TxO - Denison Cancer Center

Denison, Texas, 75020, United States
UCLA Health - Santa Monica Cancer Care

Santa Monica, California, 90404, United States
USC Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
USC Norris Oncology

Newport Beach, California, 92663, United States
Virginia Cancer Specialists

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates - Brock Cancer Center

Norfolk, Virginia, 23502, United States
Weill Cornell Medicine Sandra and Edward Meyer Cancer Center

New York, New York, 10065, United States
Weill Cornell Medicine-New York Presbyterian Hospital

New York, New York, 10021, United States

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