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Two-Drug combo tested to stop Post-Surgery nausea

NCT ID NCT07813897

Prevention Sponsor: Bangladesh Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers test whether combining palonosetron and dexamethasone prevents postoperative nausea and vomiting better than palonosetron alone. The trial enrolls 76 women aged 20 to 40 undergoing gynaecological laparoscopic surgery. Participants receive either the combination or palonosetron alone before anaesthesia, and researchers track nausea and vomiting episodes for 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
palonosetron combined with dexamethasone
What this could lead to
If the combination works better, it could become a standard preventive approach for nausea and vomiting after gynaecological laparoscopic surgery.
What could go wrong
This is a small, single-center Phase 4 trial in a narrow group of healthy women. The results may not apply to other surgeries or patients with different risk factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

76 people

The number who actually took part.

Started

Sep 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients undergoing gynaecological laparoscopic surgery * ASA physical status I and II * Age 20-40 years * Provided informed consent Exclusion Criteria: * Pregnancy * Menstruation * Gastroesophageal reflux disease * BMI \>35 kg/m² * Allergy or contraindication to study drug

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Conditions

The condition(s) this trial relates to.

Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative nausea and vomiting

Contacts and locations

Locations

  • Bangladesh Medical University

    Dhaka, 100, Bangladesh

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