Cure My Disease

Don't miss your cure!

 Log in / Sign up

A Multi-Pronged attack on Post-Surgery nausea: a new trial for head and neck cancer patients

NCT ID NCT07786155

Symptom relief Sponsor: Seoul National University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 25, 2026 · Last updated Aug 27, 2026 · Updated 2 times

Summary

This trial tests whether a combination of antiemetic strategies can better prevent postoperative nausea and vomiting (PONV) in patients undergoing flap surgery for head and neck cancer. Participants will be randomly assigned to receive either a standard antiemetic protocol or a multimodal one that includes total intravenous anesthesia, a nerve block, and three different antiemetic medications. The study will compare the number of nausea and vomiting episodes, pain levels, and overall recovery quality between the two groups.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A multimodal antiemetic protocol combining total intravenous anesthesia with propofol, a superficial cervical plexus block, and medications (dexamethasone, palonosetron, acetaminophen)
What this could lead to
If effective, this approach could offer a better way to prevent postoperative nausea and vomiting, improving recovery and comfort for head and neck cancer surgery patients.
What could go wrong
This is a small, early-stage trial, and the results may not apply to all patients. The added interventions carry their own risks, such as nerve block complications or drug side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 72 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 19 years or older undergoing elective flap surgery for head and neck cancer Exclusion Criteria: * Patients who do not consent to participate in the study * Patients undergoing emergency surgery * Patients with signs of inflammation (such as erythema) at the nerve block injection site * Patients with a history of hypersensitivity or adverse reactions to ropivacaine * Patients with difficulty completing questionnaires due to conditions such as dementia or delirium * Patients with severe cardiopulmonary disease * Patients with QT prolongation on preoperative ECG Patients deemed unsuitable for participation by the investigator

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Head and neck cancer are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

head and neck cancer Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative nausea and vomiting

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.