New hope for advanced breast cancer: switching hormone therapy while keeping targeted drug
NCT ID NCT02738866
First seen Dec 16, 2025 · Last updated May 14, 2026 · Updated 23 times
Summary
This study tests whether continuing the targeted therapy palbociclib while switching to a different hormone therapy (fulvestrant) can help people with a certain type of advanced breast cancer (hormone receptor-positive, HER2-negative) whose disease has worsened despite initial treatment. About 60 participants who have already progressed on palbociclib plus an aromatase inhibitor will receive the new combination. The goal is to see how long the cancer stays under control and to study genetic markers that may influence response.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Allegheny Health Network (AHN) - Allegheny General Hospital ONLY
Pittsburgh, Pennsylvania, 15212, United States
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Anne Arundel Health System Research Institute, Inc.
Annapolis, Maryland, 21401, United States
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Kimmel Cancer Center at Johns Hopkins at Sibley Memorial Hospital
Washington D.C., District of Columbia, 20016, United States
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Reading Hospital - McGlinn Cancer Institute
West Reading, Pennsylvania, 19611, United States
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Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, 21287, United States
Conditions
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