New combo therapy aims to ease chronic pain without opioids

NCT ID NCT04395001

First seen Nov 01, 2025 · Last updated May 12, 2026 · Updated 28 times

Summary

This study looked at whether taking a non-opioid medication (duloxetine) together with web-based pain-coping skills training helps people with long-term muscle and joint pain. About 280 adults with daily pain for at least 3 months took part. The goal was to see if this combined approach reduces pain severity and improves physical function.

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Contacts and locations

Locations

  • Wake Forest Baptist Health Department of Rheumatology

    Winston-Salem, North Carolina, 27157, United States

Conditions

Explore the condition pages connected to this study.