New triple nerve block may offer better pain relief after knee surgery
NCT ID NCT07705230
First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time
Summary
This trial tests whether a combination of three ultrasound-guided nerve blocks (adductor canal, superior genicular, and anterior femoral cutaneous nerves) provides better pain relief after total knee replacement than the standard method of injecting anesthetic around the knee joint. The study includes 64 adults scheduled for knee replacement. The main goal is to see how long it takes for pain to return after surgery, with secondary measures including painkiller use and heart rate.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a triple nerve block (adductor canal, superior genicular, and anterior femoral cutaneous blocks) using bupivacaine and dexamethasone, compared with periarticular infiltration of bupivacaine, ketorolac, adrenaline, and tranexamic acid
- What this could lead to
- If the triple nerve block works better, it could mean less pain and less need for strong painkillers after knee replacement surgery.
- What could go wrong
- This is a small, early-stage trial with 64 people, so results may not apply to everyone. Nerve blocks carry risks like infection or nerve damage, though rare.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Qassim University Medical City
Buraidah, Al-Qassim Region, Saudi Arabia
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