New triple nerve block may offer better pain relief after knee surgery
NCT ID NCT07705230
First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time
Summary
This trial tests whether a combination of three ultrasound-guided nerve blocks (adductor canal, superior genicular, and anterior femoral cutaneous nerves) provides better pain relief after total knee replacement than the standard method of injecting anesthetic around the knee joint. The study includes 64 adults scheduled for knee replacement. The main goal is to see how long it takes for pain to return after surgery, with secondary measures including painkiller use and heart rate.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- a triple nerve block (adductor canal, superior genicular, and anterior femoral cutaneous blocks) using bupivacaine and dexamethasone, compared with periarticular infiltration of bupivacaine, ketorolac, adrenaline, and tranexamic acid
- What this could lead to
- If the triple nerve block works better, it could mean less pain and less need for strong painkillers after knee replacement surgery.
- What could go wrong
- This is a small, early-stage trial with 64 people, so results may not apply to everyone. Nerve blocks carry risks like infection or nerve damage, though rare.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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64 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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Jul 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. ASA: I \& II 2. Gender: Male \& Female 3. Age: 18and above 4. BMI less than 40 kg/m2 5. Patients are scheduled for primary unilateral total knee arthroplasty. Exclusion Criteria: 1. Patients with contraindications to spinal anesthesia 2. Failed spinal anesthesia. 3. ASA III-IV 4. Body mass index (BMI)≥40, 5. A known allergy or contraindication to the drugs used in this study. 6. Previous knee surgery. 7. Renal impairment. 8. Patients who suffer from chronic neuropathic pain or on regular pain medications other than NSAIDs.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Qassim University Medical City
Buraidah, Al-Qassim Region, Saudi Arabia
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